Pseudomonas aeruginosa UCBPP-PA14, PA14_59060 (tprA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_59060
Name
tprA
Replicon chromosome
Genomic location 5260143 - 5260397 (+ strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
CommentBinds promoter at region

Cross-References

RefSeq YP_792903.1
GI 116052588
Entrez 4382697
INSDC ABJ13824.1
NCBI Locus Tag PA14_59060
UniParc UPI00001B257C
UniProtKB Acc Q02GN3
UniProtKB ID Q02GN3_PSEAB
UniRef100 UniRef100_Q02GN3
UniRef50 UniRef50_Q02GN3
UniRef90 UniRef90_Q02GN3

Product

Feature Type CDS
Coding Frame 1
Product Name
TprA
Product Name Confidence: Class 1
Synonyms Transfer of PAPI-1 regulator A
Evidence for Translation
Charge (pH 7) -0.77
Kyte-Doolittle Hydrophobicity Value -0.692
Molecular Weight (kDa) 9.6
Isoelectric Point (pI) 5.90

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 8 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG014395 (135 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_59060
Search term: tprA
Search term: TprA

Human Homologs

References

The horizontal transfer of Pseudomonas aeruginosa PA14 ICE PAPI-1 is controlled by a transcriptional triad between TprA, NdpA2 and MvaT.
Dangla-Pélissier G, Roux N, Schmidt V, Chambonnier G, Ba M, Sebban-Kreuzer C, de Bentzmann S, Giraud C, Bordi C
Nucleic Acids Res 2021 Nov 8;49(19):10956-10974
PubMed ID: 34643711