Pseudomonas aeruginosa UCBPP-PA14, PA14_42860 (mhr)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_42860
Name
mhr
Replicon chromosome
Genomic location 3809384 - 3809845 (- strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq YP_791573.1
GI 116049622
Entrez 4382935
INSDC ABJ10858.1
NCBI Locus Tag PA14_42860
UniParc UPI000012C5BD
UniProtKB Acc Q02KG3
UniProtKB ID HEMTB_PSEAB
UniRef100 UniRef100_B7UV48
UniRef50 UniRef50_B7UV48
UniRef90 UniRef90_B7UV48

Product

Feature Type CDS
Coding Frame 1
Product Name
microoxic hemerythrin, Mhr
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -4.60
Kyte-Doolittle Hydrophobicity Value -0.517
Molecular Weight (kDa) 17.9
Isoelectric Point (pI) 6.17

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 139 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003717 (313 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_42860
Search term: mhr

Human Homologs

References

Pseudomonas aeruginosa lasR mutant fitness in microoxia is supported by an Anr-regulated oxygen-binding hemerythrin.
Clay ME, Hammond JH, Zhong F, Chen X, Kowalski CH, Lee AJ, Porter MS, Hampton TH, Greene CS, Pletneva EV, Hogan DA
Proc Natl Acad Sci U S A 2020 Feb 11;117(6):3167-3173
PubMed ID: 31980538