Pseudomonas aeruginosa UCBPP-PA14, PA14_39960 (phzB2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_39960
Name
phzB2
Replicon chromosome
Genomic location 3560720 - 3561208 (- strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq YP_791339.1
GI 116049854
Entrez 4385620
INSDC ABJ11090.1
NCBI Locus Tag PA14_39960
UniParc UPI00000D423E
UniProtKB Acc Q02L47
UniProtKB ID PHZB2_PSEAB
UniRef100 UniRef100_Q02L47
UniRef50 UniRef50_Q02L47
UniRef90 UniRef90_Q02L47

Product

Feature Type CDS
Coding Frame 1
Product Name
phenazine biosynthesis protein
Synonyms
Evidence for Translation
Charge (pH 7) -2.65
Kyte-Doolittle Hydrophobicity Value -0.670
Molecular Weight (kDa) 19.0
Isoelectric Point (pI) 6.24

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3FF0 BIOSYNTHETIC PROTEIN 12/01/08 Crystal structure of a phenazine biosynthesis-related protein (phzb2) from pseudomonas aeruginosa at 1.90 A resolution Pseudomonas aeruginosa 1.9 X-RAY DIFFRACTION 100.0

Virulence Evidence

Source 1
Database PseudoCAP
Category Phenazine biosynthesis
Evidence ECO:0000316
genetic interaction evidence used in manual assertion
Host Organism Mus musculus
Notes phz2 operon, but not phz1 operon required for lung colonization in acute mouse pulmonary Infection model
Infection model acute mouse pulmonary Infection model
Reference 23129634

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 6 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003512 (231 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_39960
Search term: phzB2

Human Homologs

References

No references are associated with this feature.