Pseudomonas aeruginosa UCBPP-PA14, PA14_33680 (fpvA)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest |
| Locus Tag |
PA14_33680
|
| Name |
fpvA
|
| Replicon | chromosome |
| Genomic location | 2986159 - 2988606 (- strand) |
| Transposon Mutants | 1 transposon mutants in UCBPP-PA14 |
| Transposon Mutants in orthologs | 11 transposon mutants in orthologs |
Cross-References
| RefSeq | YP_790844.1 |
| GI | 116050339 |
| Entrez | 4380460 |
| NCBI Locus Tag | PA14_33680 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
ferripyoverdine receptor
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -14.61 |
| Kyte-Doolittle Hydrophobicity Value | -0.560 |
| Molecular Weight (kDa) | 91.2 |
| Isoelectric Point (pI) | 5.28 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 2IAH | MEMBRANE PROTEIN | 09/08/06 | Crystal structure of the ferripyoverdine receptor of the outer membrane of Pseudomonas aeruginosa bound to ferripyoverdine. | Pseudomonas aeruginosa; SYNTHETIC CONSTRUCT | 2.73 | X-RAY DIFFRACTION | 99.9 |
| 2W77 | RECEPTOR | 12/20/08 | Structures of P. aeruginosa FpvA bound to heterologous pyoverdines: FpvA-Pvd(Pfl18.1)-Fe complex | PSEUDOMONAS AERUGINOSA; PSEUDOMONAS FLUORESCENS | 2.9 | X-RAY DIFFRACTION | 99.9 |
| 1XKH | MEMBRANE PROTEIN | 09/29/04 | Pyoverdine outer membrane receptor FpvA from Pseudomonas aeruginosa PAO1 bound to pyoverdine | Pseudomonas aeruginosa; SYNTHETIC CONSTRUCT | 3.6 | X-RAY DIFFRACTION | 100.0 |
| 2W76 | RECEPTOR | 12/20/08 | Structures of P. aeruginosa FpvA bound to heterologous pyoverdines: FpvA-Pvd(Pa6)-Fe complex | PSEUDOMONAS AERUGINOSA | 2.8 | X-RAY DIFFRACTION | 99.9 |
| 2W16 | MEMBRANE PROTEIN | 10/14/08 | Structures of FpvA bound to heterologous pyoverdines | PSEUDOMONAS AERUGINOSA | 2.71 | X-RAY DIFFRACTION | 99.9 |
| 2W75 | RECEPTOR | 12/20/08 | Structures of P. aeruginosa FpvA bound to heterologous pyoverdines: Apo-FpvA | PSEUDOMONAS AERUGINOSA | 2.9 | X-RAY DIFFRACTION | 99.9 |
| 5ODW | PROTEIN TRANSPORT | 07/06/17 | Structure of the FpvAI-pyocin S2 complex | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 2.8 | X-RAY DIFFRACTION | 99.8 |
| 2W6U | MEMBRANE PROTEIN | 12/19/08 | Structures of P. aeruginosa FpvA bound to heterologous pyoverdines: FpvA-Pvd(G173)-Fe complex | PSEUDOMONAS AERUGINOSA; PSEUDOMONAS FLUORESCENS | 3 | X-RAY DIFFRACTION | 99.9 |
| 2O5P | TRANSPORT PROTEIN | 12/06/06 | Crystal structure of the full length ferric pyoverdine outer membrane receptor FpvA of Pseudomonas aeruginosa in its apo form | Pseudomonas aeruginosa | 2.77 | X-RAY DIFFRACTION | 99.9 |
| 2W6T | MEMBRANE PROTEIN | 12/19/08 | Structures of P. aeruginosa FpvA bound to heterologous pyoverdines: FpvA-Pvd(DSM50106)-Fe complex | PSEUDOMONAS AERUGINOSA; PSEUDOMONAS FLUORESCENS | 2.9 | X-RAY DIFFRACTION | 99.9 |
| 2W78 | RECEPTOR | 12/20/08 | Structures of P. aeruginosa FpvA bound to heterologous pyoverdines: FpvA-Pvd(ATCC13535)-Fe complex | PSEUDOMONAS AERUGINOSA | 3 | X-RAY DIFFRACTION | 99.9 |
Drugs Targeting this Protein
Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.
| Drug Name | Source Accession | Source DB | Version | Target Accession | Target Description | Percent Identity | Alignment Length | E-Value |
| 3,6,9,12,15-PENTAOXATRICOSAN-1-OL | DB08249 | DrugBank | 5.1.4 | P48632 | Ferripyoverdine receptor | 99.8 | 815 | 0.0e+00 |
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 271 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG001486 (1037 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PA14_33680
Search term: fpvA
Search term: ferripyoverdine receptor
|
Human Homologs
References
No references are associated with this feature.