Pseudomonas aeruginosa UCBPP-PA14, PA14_25690 (fabF1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_25690
Name
fabF1
Replicon chromosome
Genomic location 2244526 - 2245770 (+ strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq YP_790208.1
GI 116050967
EC Number 2.3.1.41
Entrez 4384346
INSDC ABJ12203.1
NCBI Locus Tag PA14_25690
UniParc UPI00000D428F
UniProtKB Acc Q02PC8
UniProtKB ID Q02PC8_PSEAB
UniRef100 UniRef100_G3XDA2
UniRef50 UniRef50_Q9KQH9
UniRef90 UniRef90_G3XDA2

Product

Feature Type CDS
Coding Frame 1
Product Name
3-oxoacyl-ACP synthase
Synonyms
Evidence for Translation
Charge (pH 7) -6.74
Kyte-Doolittle Hydrophobicity Value -0.029
Molecular Weight (kDa) 43.5
Isoelectric Point (pI) 5.81

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
7OC1 ANTIBIOTIC 04/25/21 Structure of Pseudomonas aeruginosa FabF mutant C164Q in complex with Platensimycin Pseudomonas aeruginosa 1.8 X-RAY DIFFRACTION 99.8
4JB6 TRANSFERASE 02/19/13 Structure of Pseudomonas aeruginosa FabF mutant C164Q Pseudomonas aeruginosa 2.4 X-RAY DIFFRACTION 99.8
4B7V TRANSFERASE 08/22/12 Structure of wild type Pseudomonas aeruginosa FabF (KASII) PSEUDOMONAS AERUGINOSA 1.73 X-RAY DIFFRACTION 100.0
7OC0 ANTIBIOTIC 04/25/21 Structure of Pseudomonas aeruginosa FabF mutant C164Q in complex with a ligand (2S,4R)-2-(thiophen-2-yl)thiazolidine-4-carboxylic acid Pseudomonas aeruginosa PAO1 1.78 X-RAY DIFFRACTION 99.8
4JPF TRANSFERASE 03/19/13 Structure of wild type Pseudomonas aeruginosa FabF (KASII) in Complex with ligand Pseudomonas aeruginosa 1.67 X-RAY DIFFRACTION 100.0

Virulence Evidence

Source 1
Database Victors : 4423
Category
Evidence ECO:0000015
mutant phenotype evidence
Host Organism Drosophila melanogaster
Notes
Reference 18591226
Source 2
Database Victors : 4423
Category
Evidence ECO:0000015
mutant phenotype evidence
Host Organism Mus musculus
Notes
Reference 18591226
Source 3
Database PseudoCAP
Category
Evidence ECO:0000015
mutant phenotype evidence
Host Organism Caenorhabditis elegans
Notes
Infection model C. elegans slow killing assay.
Reference 22911607

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 572 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002617 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_25690
Search term: fabF1

Human Homologs

Ensembl 110, assembly GRCh38.p14
3-oxoacyl-ACP synthase, mitochondrial [Source:HGNC Symbol;Acc:HGNC:26063]
E-value: 3.2e-97
Percent Identity: 47.4

References

No references are associated with this feature.