Pseudomonas aeruginosa UCBPP-PA14, PA14_25550 (murB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_25550
Name
murB
Replicon chromosome
Genomic location 2232097 - 2233116 (+ strand)

Cross-References

RefSeq YP_790196.1
GI 116050979
EC Number 1.1.1.158
EC Number 1.3.1.98
Entrez 4381003
INSDC ABJ12215.1
NCBI Locus Tag PA14_25550
UniParc UPI0000395F60
UniProtKB Acc Q02PE0
UniProtKB ID Q02PE0_PSEAB
UniRef100 UniRef100_Q02PE0
UniRef50 UniRef50_Q9HZM7
UniRef90 UniRef90_Q9HZM7

Product

Feature Type CDS
Coding Frame 1
Product Name
UDP-N-acetylenolpyruvoylglucosamine reductase
Synonyms
Evidence for Translation
Charge (pH 7) -1.87
Kyte-Doolittle Hydrophobicity Value -0.254
Molecular Weight (kDa) 37.6
Isoelectric Point (pI) 6.39

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
7ORZ OXIDOREDUCTASE 06/06/21 Crystal structure of UDP-N-acetylenolpyruvoylglucosamine reductase (MurB) from Pseudomonas aeruginosa in complex with FAD and a pyrazole derivative (fragment 18) Pseudomonas aeruginosa PAO1 1.85 X-RAY DIFFRACTION 99.4
4JB1 OXIDOREDUCTASE 02/19/13 Crystal structure of P. aeruginosa MurB in complex with NADP+ Pseudomonas aeruginosa 2.1 X-RAY DIFFRACTION 99.4
7OSQ OXIDOREDUCTASE 06/09/21 Crystal structure of UDP-N-acetylenolpyruvoylglucosamine reductase (MurB) from Pseudomonas aeruginosa in complex with FAD and a pyrazole derivative (fragment 18) Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.07 X-RAY DIFFRACTION 99.4
4JAY OXIDOREDUCTASE 02/19/13 Crystal structure of P. aeruginosa MurB in complex with NADP+ Pseudomonas aeruginosa 2.23 X-RAY DIFFRACTION 99.4
7OR2 OXIDOREDUCTASE 06/04/21 Crystal structure of UDP-N-acetylenolpyruvoylglucosamine reductase (MurB) from Pseudomonas aeruginosa in complex with FAD and a pyrazole derivative (fragment 4) Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.35 X-RAY DIFFRACTION 99.4

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 548 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002605 (534 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_25550
Search term: murB

Human Homologs

References

No references are associated with this feature.