Pseudomonas aeruginosa BWHPSA044, Q049_03912

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa BWHPSA044
GCF_000520315.1|latest
Locus Tag
Q049_03912
Name
Replicon adkfY-supercont1.1
Genomic location 4247586 - 4248584 (+ strand)

Cross-References

RefSeq WP_003086252.1
GI 489176730
NCBI Locus Tag Q049_03912

Product

Feature Type CDS
Coding Frame 1
Product Name
transcriptional regulator
Synonyms
Evidence for Translation
Charge (pH 7) 1.77
Kyte-Doolittle Hydrophobicity Value -0.131
Molecular Weight (kDa) 37.2
Isoelectric Point (pI) 7.56

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
7QA0 GENE REGULATION 11/15/21 Crystal structure of PqsR (MvfR) ligand-binding domain in complex with compound 1456 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.67 X-RAY DIFFRACTION 99.7
6Z07 DNA BINDING PROTEIN 05/07/20 PqsR (MvfR) in complex with antagonist 12 Pseudomonas aeruginosa (strain UCBPP-PA14) 2.95 X-RAY DIFFRACTION 100.0
6B8A TRANSCRIPTION 10/05/17 Crystal structure of MvfR ligand binding domain in complex with M64 Pseudomonas aeruginosa 2.65 X-RAY DIFFRACTION 100.0
6Q7W DNA BINDING PROTEIN 12/13/18 Crystal structure of PqsR (MvfR) ligand-binding domain in complex with compound 20 Pseudomonas aeruginosa PAO1 2.82 X-RAY DIFFRACTION 99.6
6Q7V DNA BINDING PROTEIN 12/13/18 Crystal structure of PqsR (MvfR) ligand-binding domain in complex with compound 11 Pseudomonas aeruginosa PAO1 2.56 X-RAY DIFFRACTION 99.6
7NBW DNA BINDING PROTEIN 01/28/21 Crystal structure of PqsR (MvfR) ligand-binding domain in complex with a pyridin agonist Pseudomonas aeruginosa PAO1 2.28 X-RAY DIFFRACTION 99.6
6TPR DNA BINDING PROTEIN 12/14/19 PqsR (MvfR) bound to inhibitory compound 40 Pseudomonas aeruginosa UCBPP-PA14 3.2 X-RAY DIFFRACTION 100.0
7O2U DNA BINDING PROTEIN 03/31/21 PqsR (MvfR) in complex with antagonist 40 Pseudomonas aeruginosa 3 X-RAY DIFFRACTION 100.0
7O2T DNA BINDING PROTEIN 03/31/21 PqsR (MvfR) in complex with antagonist 61 Pseudomonas aeruginosa 2.65 X-RAY DIFFRACTION 100.0
4JVC TRANSCRIPTION REGULATOR 03/25/13 Crystal structure of PqsR co-inducer binding domain Pseudomonas aeruginosa 2.5 X-RAY DIFFRACTION 100.0
7QAV GENE REGULATION 11/17/21 Crystal structure of PqsR (MvfR) ligand-binding domain in complex with compound N-((2-(4-cyclopropylphenyl)thiazol-5-yl)methyl)-2-(trifluoromethyl)pyridin-4-amine Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.65 X-RAY DIFFRACTION 99.4
6Q7U DNA BINDING PROTEIN 12/13/18 Crystal structure of PqsR (MvfR) ligand-binding domain in complex with HHQ Pseudomonas aeruginosa PAO1 3.14 X-RAY DIFFRACTION 99.6
7QA3 GENE REGULATION 11/15/21 Crystal structure of PqsR (MvfR) ligand-binding domain in complex with compound N-((2-(4-phenoxyphenyl)thiazol-5-yl)methyl)-2-(trifluoromethyl)pyridin-4-amine Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.67 X-RAY DIFFRACTION 99.7
6Z5K DNA BINDING PROTEIN 05/26/20 PqsR (MvfR) in complex with antagonist 18 Pseudomonas aeruginosa (strain UCBPP-PA14) 3.201 X-RAY DIFFRACTION 100.0
6YZ3 DNA BINDING PROTEIN 05/06/20 PqsR (MvfR) in complex with antagonist 19 Pseudomonas aeruginosa 3 X-RAY DIFFRACTION 100.0
7P4U GENE REGULATION 07/13/21 Crystal structure of PqsR (MvfR) ligand-binding domain in complex with 3-PYRIDIN-4-YL-2,4-DIHYDRO-INDENO[1,2-.C.]PYRAZOLE Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.74 X-RAY DIFFRACTION 99.6
4JVI TRANSCRIPTION REGULATOR/INHIBITOR 03/25/13 Crystal structure of PqsR co-inducer binding domain of Pseudomonas aeruginosa with inhibitor 3NH2-7Cl-C9QZN Pseudomonas aeruginosa 2.9 X-RAY DIFFRACTION 100.0
6YIZ DNA BINDING PROTEIN 04/01/20 Crystal structure of PqsR (MvfR) ligand-binding domain in complex with triazolo-pyridine inverse agonist A Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.163 X-RAY DIFFRACTION 99.6
6Z17 DNA BINDING PROTEIN 05/12/20 PqsR (MvfR) in complex with antagonist 6 Pseudomonas aeruginosa (strain UCBPP-PA14) 3.15 X-RAY DIFFRACTION 100.0
4JVD TRANSCRIPTION REGULATOR 03/25/13 Crystal structure of PqsR coinducer binding domain of Pseudomonas aeruginosa with ligand NHQ Pseudomonas aeruginosa 2.95 X-RAY DIFFRACTION 100.0

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000966 (291 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: Q049_03912

Human Homologs

References

No references are associated with this feature.