Pseudomonas aeruginosa 3576, AJ63_05455

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa 3576
GCF_000629265.1|latest
Locus Tag
AJ63_05455
Name
Replicon adVri-supercont1.36
Genomic location 16549 - 17181 (- strand)

Cross-References

RefSeq WP_003121711.1
GI 489212966
NCBI Locus Tag AJ63_05455

Product

Feature Type CDS
Coding Frame 1
Product Name
TetR family transcriptional regulator
Synonyms
Evidence for Translation
Charge (pH 7) 1.06
Kyte-Doolittle Hydrophobicity Value -0.401
Molecular Weight (kDa) 23.8
Isoelectric Point (pI) 7.75

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
MexZ MexZ is a transcriptional regulator that downregulates the mexXY multidrug transporter operon, which confers to aminoglycoside resistance on Pseudomonas aeruginosa. [PMID:15336398] ARO:3003709 protein overexpression model Strict 417.2 99.52 3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2WUI TRANSCRIPTION 10/05/09 Crystal Structure of MexZ, a key repressor responsible for antibiotic resistance in Pseudomonas aeruginosa. PSEUDOMONAS AERUGINOSA 2.9 X-RAY DIFFRACTION 99.5

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003420 (237 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: AJ63_05455

Human Homologs

References

No references are associated with this feature.