Pseudomonas aeruginosa BWH052, V553_05077

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa BWH052
GCF_000629545.1|latest
Locus Tag
V553_05077
Name
Replicon adTvf-supercont1.5
Genomic location 476222 - 477625 (+ strand)
Partial sequence -> 3' end.

Cross-References

RefSeq WP_031631704.1
GI 685890362
NCBI Locus Tag V553_05077

Product

Feature Type CDS
Coding Frame 1
Product Name
multidrug transporter
Synonyms
Evidence for Translation
Charge (pH 7) -2.79
Kyte-Doolittle Hydrophobicity Value -0.155
Molecular Weight (kDa) 50.7
Isoelectric Point (pI) 5.30

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
OprM OprM is an outer membrane factor protein found in Pseudomonas aeruginosa and Burkholderia vietnamiensis. It is part of the MexAB-OprM, MexVW-OprM, MexXY-OprM and the AmrAB-OprM complex. [PMID:16508113, PMID:16511029, PMID:15797729] ARO:3000379 protein homolog model Strict 886.7 100.0 3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6TA5 ANTIMICROBIAL PROTEIN 10/29/19 OprM-MexA complex from the MexAB-OprM Pseudomonas aeruginosa whole assembly reconstituted in nanodiscs Pseudomonas aeruginosa 3.2 ELECTRON MICROSCOPY 100.0
6IOK MEMBRANE PROTEIN 10/30/18 Cryo-EM structure of multidrug efflux pump MexAB-OprM (0 degree state) Pseudomonas aeruginosa PAO1 3.64 ELECTRON MICROSCOPY 100.0
3D5K MEMBRANE PROTEIN 05/16/08 Crystal structure of the OprM channel in a non-symmetrical space group Pseudomonas aeruginosa 2.4 X-RAY DIFFRACTION 100.0
1WP1 MEMBRANE PROTEIN 08/28/04 Crystal structure of the drug-discharge outer membrane protein, OprM Pseudomonas aeruginosa 2.56 X-RAY DIFFRACTION 100.0
6ZRE TRANSLOCASE 07/13/20 Deciphering the role of the channel constrictions in the opening mechanism of MexAB-OprM efflux pump from Pseudomonas aeruginosa Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.8 X-RAY DIFFRACTION 100.0
6IOL MEMBRANE PROTEIN 10/30/18 Cryo-EM structure of multidrug efflux pump MexAB-OprM (60 degree state) Pseudomonas aeruginosa; Pseudomonas aeruginosa PAO1 3.76 ELECTRON MICROSCOPY 100.0
4Y1K MEMBRANE PROTEIN 02/07/15 PALMITOYLATED OPRM OUTER MEMBRANE FACTOR Pseudomonas aeruginosa 3.8 X-RAY DIFFRACTION 100.0
6TA6 ANTIMICROBIAL PROTEIN 10/29/19 MexAB assembly of the Pseudomonas MexAB-OprM efflux pump reconstituted in nanodiscs Pseudomonas aeruginosa 3.2 ELECTRON MICROSCOPY 100.0
7AKZ TRANSLOCASE 10/02/20 Deciphering the role of the channel constrictions in the opening mechanism of MexAB-OprM efflux pump from Pseudomonas aeruginosa Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 3.2 X-RAY DIFFRACTION 100.0

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000418 (534 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: V553_05077

Human Homologs

References

No references are associated with this feature.