Pseudomonas aeruginosa PAO1, PA0423.1 (AS1974)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA0423.1
Name
AS1974
Replicon chromosome
Genomic location 471298 - 471425 (+ strand)
CommentBinds to Hfq with high specificity
CommentOverexpression of AS1974 was able to transform a MDR clinical strain to drug hypersusceptibility
CommentDownregulated in all drug-resistant strains compared with all drug-susceptible strains.
CommentAS1974 sRNA expression is regulated by methylation in all MDR strains examined (PMID:30901580)

Cross-References

Product

Feature Type ncRNA
Product Name
AS1974
Product Name Confidence: Class 1
Evidence for Translation

Subcellular localization

Additional evidence for subcellular localization

Pathogen Association Analysis

References

A Small RNA Transforms the Multidrug Resistance of Pseudomonas aeruginosa to Drug Susceptibility.
Law COK, Huang C, Pan Q, Lee J, Hao Q, Chan TF, Lo NWS, Ang IL, Koon A, Ip M, Chan E, Lau TCK
Mol Ther Nucleic Acids 2019 Jun 7;16:218-228
PubMed ID: 30901580