Pseudomonas aeruginosa PA1R, PA1R_gp1373
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa PA1R
GCF_000496645.1|latest |
| Locus Tag |
PA1R_gp1373
|
| Name |
|
| Replicon | chromosome |
| Genomic location | 1549459 - 1551447 (+ strand) |
Cross-References
| RefSeq | YP_008804021.1 |
| GI | 558667311 |
| EC Number | 4.1.1.- |
| Entrez | 17677504 |
| NCBI Locus Tag | PA1R_gp1373 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
Polymyxin resistance protein ArnA_DH, UDP-glucuronic acid decarboxylase
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -3.48 |
| Kyte-Doolittle Hydrophobicity Value | -0.254 |
| Molecular Weight (kDa) | 74.3 |
| Isoelectric Point (pI) | 6.68 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AMR gene predictions from CARD database
Identified using the Resistance Gene Identifier (RGI)
| Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
| arnA | arnA modifies lipid A with 4-amino-4-deoxy-L-arabinose (Ara4N) which allows gram-negative bacteria to resist the antimicrobial activity of cationic antimicrobial peptides and antibiotics such as polymyxin. arnA is found in E. coli and P. aeruginosa. [PMID:11021929, PMID:15939024] | ARO:3002985 | protein homolog model | Strict | 1354.7 | 99.55 | 3.2.5 |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
Pathogen Association Analysis
| Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 651 genera
|
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG002112 (427 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: PA1R_gp1373
|
Human Homologs
|
Ensembl
110, assembly
GRCh38.p14
|
UDP-glucuronate decarboxylase 1 [Source:HGNC Symbol;Acc:HGNC:17729]
E-value:
4.3e-27
Percent Identity:
27.4
|
|
Ensembl
110, assembly
GRCh38.p14
|
UDP-glucuronate decarboxylase 1 [Source:HGNC Symbol;Acc:HGNC:17729]
E-value:
4.3e-27
Percent Identity:
27.4
|
References
No references are associated with this feature.