Pseudomonas aeruginosa BWHPSA001, Q014_03958
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Feature Overview
| Strain |
Pseudomonas aeruginosa BWHPSA001
GCF_000481685.1|latest |
| Locus Tag |
Q014_03958
|
| Name |
|
| Replicon | scaffold_2 |
| Genomic location | 1187279 - 1189291 (+ strand) |
Cross-References
| RefSeq | WP_016253774.1 |
| GI | 510933526 |
| NCBI Locus Tag | Q014_03958 |
Product
| Feature Type | CDS |
| Coding Frame | 1 |
| Product Name |
neutral ceramidase
|
| Synonyms | |
| Evidence for Translation | |
| Charge (pH 7) | -5.76 |
| Kyte-Doolittle Hydrophobicity Value | -0.250 |
| Molecular Weight (kDa) | 73.3 |
| Isoelectric Point (pI) | 6.29 |
Subcellular localization
| Individual Mappings | |
| Additional evidence for subcellular localization |
AlphaFold 2 Protein Structure Predictions
Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.
PDB 3D Structures
| Accession | Header | Accession Date | Compound | Source | Resolution | Method | Percent Identity |
| 2ZXC | HYDROLASE | 12/22/08 | Ceramidase complexed with C2 | Pseudomonas aeruginosa | 2.2 | X-RAY DIFFRACTION | 99.8 |
| 2ZWS | HYDROLASE | 12/17/08 | Crystal Structure Analysis of neutral ceramidase from Pseudomonas aeruginosa | Pseudomonas aeruginosa | 1.4 | X-RAY DIFFRACTION | 99.8 |
Drugs Targeting this Protein
Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.
| Drug Name | Source Accession | Source DB | Version | Target Accession | Target Description | Percent Identity | Alignment Length | E-Value |
| N-[(1R,2R,3E)-2-hydroxy-1-(hydroxymethyl)heptadec-3-en-1-yl]acetamide | DB06960 | DrugBank | 5.1.4 | Q9I596 | Neutral ceramidase | 99.7 | 670 | 0.0e+00 |
Orthologs/Comparative Genomics
| Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
| Pseudomonas Ortholog Group |
POG000812 (298 members) |
| Putative Inparalogs | None Found |
Interactions
| STRING database | Search for predicted protein-protein interactions using:
Search term: Q014_03958
Search term: neutral ceramidase
|
Human Homologs
|
Ensembl
110, assembly
GRCh38.p14
|
N-acylsphingosine amidohydrolase 2 [Source:HGNC Symbol;Acc:HGNC:18860]
E-value:
5.4e-118
Percent Identity:
36.1
|
|
Ensembl
110, assembly
GRCh38.p14
|
N-acylsphingosine amidohydrolase 2 [Source:HGNC Symbol;Acc:HGNC:18860]
E-value:
5.4e-118
Percent Identity:
36.1
|
References
No references are associated with this feature.