Pseudomonas aeruginosa PAO1, PA5256 (dsbH)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5256
Name
dsbH
Synonym: dsbB
Replicon chromosome
Genomic location 5917680 - 5918171 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_253943.1
GI 15600449
Affymetrix PA5256_dsbH_at
DNASU PaCD00008266
Entrez 879720
GenBank AAG08641.1
INSDC AAG08641.1
NCBI Locus Tag PA5256
protein_id(GenBank) gb|AAG08641.1|AE004938_3|gnl|PseudoCAP|PA5256
TIGR NTL03PA05257
UniParc UPI00001298B4
UniProtKB Acc P21482
UniProtKB ID DSBB1_PSEAE
UniRef100 UniRef100_P21482
UniRef50 UniRef50_P21482
UniRef90 UniRef90_P21482

Product

Feature Type CDS
Coding Frame 1
Product Name
disulfide bond formation protein
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 2.28
Kyte-Doolittle Hydrophobicity Value 0.971
Molecular Weight (kDa) 17.8
Isoelectric Point (pI) 8.12

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 99 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004837 (463 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5256
Search term: dsbH

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Nucleotide sequence of a regulatory region controlling alginate synthesis in Pseudomonas aeruginosa: characterization of the algR2 gene.
Kato J, Chu L, Kitano K, DeVault JD, Kimbara K, Chakrabarty AM, Misra TK
Gene 1989 Dec 7;84(1):31-8
PubMed ID: 2514124
The dsbB gene product is required for protease production by Burkholderia cepacia.
Abe M, Nakazawa T
Infect Immun 1996 Oct;64(10):4378-80
PubMed ID: 8926116