Pseudomonas aeruginosa PAO1, PA5068 (tatA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA5068
Name
tatA
Synonym: yigT
Synonym: mttA
Replicon chromosome
Genomic location 5706552 - 5706800 (+ strand)

Cross-References

RefSeq NP_253755.1
GI 15600261
Affymetrix PA5068_tatA_at
DNASU PaCD00008180
Entrez 878487
GenBank AAG08453.1
INSDC AAG08453.1
NCBI Locus Tag PA5068
protein_id(GenBank) gb|AAG08453.1|AE004920_3|gnl|PseudoCAP|PA5068
TIGR NTL03PA05069
UniParc UPI00001368F4
UniProtKB Acc Q9HUB5
UniProtKB ID TATA_PSEAE
UniRef100 UniRef100_B7V3G1
UniRef50 UniRef50_Q87UY7
UniRef90 UniRef90_B7V3G1

Product

Feature Type CDS
Coding Frame 1
Product Name
translocation protein TatA
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 0.47
Kyte-Doolittle Hydrophobicity Value -0.474
Molecular Weight (kDa) 9.2
Isoelectric Point (pI) 7.70

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 166 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004669 (537 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA5068
Search term: tatA

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
The complete genome sequence of Escherichia coli K-12.
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y
Science 1997 Sep 5;277(5331):1453-62
PubMed ID: 9278503
A novel and ubiquitous system for membrane targeting and secretion of cofactor-containing proteins.
Weiner JH, Bilous PT, Shaw GM, Lubitz SP, Frost L, Thomas GH, Cole JA, Turner RJ
Cell 1998 Apr 3;93(1):93-101
PubMed ID: 9546395
Overlapping functions of components of a bacterial Sec-independent protein export pathway.
Sargent F, Bogsch EG, Stanley NR, Wexler M, Robinson C, Berks BC, Palmer T
EMBO J 1998 Jul 1;17(13):3640-50
PubMed ID: 9649434
Potential receptor function of three homologous components, TatA, TatB and TatE, of the twin-arginine signal sequence-dependent metalloenzyme translocation pathway in Escherichia coli.
Chanal A, Santini C, Wu L
Mol Microbiol 1998 Nov;30(3):674-6
PubMed ID: 9822832