Pseudomonas aeruginosa PAO1, PA4975

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4975
Name
Replicon chromosome
Genomic location 5585615 - 5586319 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq NP_253662.1
GI 15600168
Affymetrix PA4975_at
DNASU PaCD00008152
Entrez 880914
GenBank AAG08360.1
INSDC AAG08360.1
NCBI Locus Tag PA4975
protein_id(GenBank) gb|AAG08360.1|AE004910_7|gnl|PseudoCAP|PA4975
TIGR NTL03PA04976
UniParc UPI00000C5EA4
UniProtKB Acc Q9HUJ0
UniProtKB ID Q9HUJ0_PSEAE
UniRef100 UniRef100_Q9HUJ0
UniRef50 UniRef50_A6VD92
UniRef90 UniRef90_A6VD92

Product

Feature Type CDS
Coding Frame 1
Product Name
NAD(P)H quinone oxidoreductase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -3.65
Kyte-Doolittle Hydrophobicity Value -0.025
Molecular Weight (kDa) 26.3
Isoelectric Point (pI) 5.95

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 286 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000820 (1495 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4975

Human Homologs

Ensembl 110, assembly GRCh38.p14
N-ribosyldihydronicotinamide:quinone reductase 2 [Source:HGNC Symbol;Acc:HGNC:7856]
E-value: 3.4e-43
Percent Identity: 43.5
Ensembl 110, assembly GRCh38.p14
N-ribosyldihydronicotinamide:quinone reductase 2 [Source:HGNC Symbol;Acc:HGNC:7856]
E-value: 3.4e-43
Percent Identity: 43.5
Ensembl 110, assembly GRCh38.p14
N-ribosyldihydronicotinamide:quinone reductase 2 [Source:HGNC Symbol;Acc:HGNC:7856]
E-value: 3.4e-43
Percent Identity: 43.5

References

Nucleotide and deduced amino acid sequence of a human cDNA (NQO2) corresponding to a second member of the NAD(P)H:quinone oxidoreductase gene family. Extensive polymorphism at the NQO2 gene locus on chromosome 6.
Jaiswal AK, Burnett P, Adesnik M, McBride OW
Biochemistry 1990 Feb 20;29(7):1899-906
PubMed ID: 1691923
Pseudomonas aeruginosa MdaB and WrbA are water-soluble two-electron quinone oxidoreductases with the potential to defend against oxidative stress.
Green LK, La Flamme AC, Ackerley DF
J Microbiol 2014 Sep;52(9):771-7
PubMed ID: 25085734