Pseudomonas aeruginosa PAO1, PA4886

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4886
Name
Replicon chromosome
Genomic location 5481070 - 5482461 (+ strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 4 transposon mutants in orthologs

Cross-References

RefSeq NP_253573.1
GI 15600079
Affymetrix PA4886_at
Entrez 877997
GenBank AAG08271.1
INSDC AAG08271.1
NCBI Locus Tag PA4886
protein_id(GenBank) gb|AAG08271.1|AE004901_13|gnl|PseudoCAP|PA4886
TIGR NTL03PA04887
UniParc UPI00000C5E5C
UniProtKB Acc Q9HUS7
UniProtKB ID Q9HUS7_PSEAE
UniRef100 UniRef100_Q9HUS7
UniRef50 UniRef50_Q48GM9
UniRef90 UniRef90_Q9HUS7

Product

Feature Type CDS
Coding Frame 1
Product Name
probable two-component sensor
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Charge (pH 7) 1.40
Kyte-Doolittle Hydrophobicity Value 0.001
Molecular Weight (kDa) 50.9
Isoelectric Point (pI) 7.40

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 617 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001355 (1379 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4886

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
A two-component regulatory system required for copper-inducible expression of the copper resistance operon of Pseudomonas syringae.
Mills SD, Jasalavich CA, Cooksey DA
J Bacteriol 1993 Mar;175(6):1656-64
PubMed ID: 8449873