Pseudomonas aeruginosa PAO1, PA4501 (opdP)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4501
Name
opdP
Synonym: opdP
Replicon chromosome
Genomic location 5038901 - 5040355 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253191.1
GI 15599697
Affymetrix PA4501_at
Entrez 881095
GenBank AAG07889.1
NCBI Locus Tag PA4501
protein_id(GenBank) gb|AAG07889.1|AE004864_1|gnl|PseudoCAP|PA4501
TIGR NTL03PA04502
UniProtKB Acc Q9HVS0
UniProtKB ID Q9HVS0_PSEAE

Product

Feature Type CDS
Coding Frame 1
Product Name
OpdP
Product Name Confidence: Class 1
Synonyms Glycine-glutamate dipeptide porin OpdP
OccD3
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -7.35
Kyte-Doolittle Hydrophobicity Value -0.479
Molecular Weight (kDa) 53.0
Isoelectric Point (pI) 5.80

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 3
Outer Membrane Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3SYB MEMBRANE PROTEIN 07/16/11 Crystal structure of Pseudomonas aeruginosa OccD3 (OpdP) Pseudomonas aeruginosa 2.7 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 16 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004088 (487 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4501
Search term: opdP
Search term: OpdP

Human Homologs

References

Role of the novel OprD family of porins in nutrient uptake in Pseudomonas aeruginosa.
Tamber S, Ochs MM, Hancock RE
J Bacteriol 2006 Jan;188(1):45-54
PubMed ID: 16352820
Involvement of two related porins, OprD and OpdP, in the uptake of arginine by Pseudomonas aeruginosa.
Tamber S, Hancock RE
FEMS Microbiol Lett 2006 Jul;260(1):23-9
PubMed ID: 16790014
Responses of carbapenemase-producing and non-producing carbapenem-resistant Pseudomonas aeruginosa strains to meropenem revealed by quantitative tandem mass spectrometry proteomics.
Salvà-Serra F, Jaén-Luchoro D, Marathe NP, Adlerberth I, Moore ERB, Karlsson R
Front Microbiol 2022;13:1089140
PubMed ID: 36845973
Toward the rational design of carbapenem uptake in Pseudomonas aeruginosa.
Isabella VM, Campbell AJ, Manchester J, Sylvester M, Nayar AS, Ferguson KE, Tommasi R, Miller AA
Chem Biol 2015 Apr 23;22(4):535-547
PubMed ID: 25910245
Understanding Carbapenem Translocation through OccD3 (OpdP) of Pseudomonas aeruginosa.
Soundararajan G, Bhamidimarri SP, Winterhalter M
ACS Chem Biol 2017 Jun 16;12(6):1656-1664
PubMed ID: 28440622
High-level resistance to meropenem in clinical isolates of Pseudomonas aeruginosa in the absence of carbapenemases: role of active efflux and porin alterations.
Chalhoub H, Sáenz Y, Rodriguez-Villalobos H, Denis O, Kahl BC, Tulkens PM, Van Bambeke F
Int J Antimicrob Agents 2016 Dec;48(6):740-743
PubMed ID: 28128097