Pseudomonas aeruginosa PAO1, PA3344 (recQ)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3344
Name
recQ
Replicon chromosome
Genomic location 3755021 - 3757159 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252034.1
GI 15598540
Affymetrix PA3344_recQ_at
Entrez 882509
GenBank AAG06732.1
INSDC AAG06732.1
NCBI Locus Tag PA3344
protein_id(GenBank) gb|AAG06732.1|AE004757_1|gnl|PseudoCAP|PA3344
TIGR NTL03PA03344
UniParc UPI00000C59C6
UniProtKB Acc Q9HYQ1
UniProtKB ID Q9HYQ1_PSEAE
UniRef100 UniRef100_W0YX66
UniRef50 UniRef50_Q4KGC8
UniRef90 UniRef90_A6V284

Product

Feature Type CDS
Coding Frame 1
Product Name
ATP-dependent DNA helicase RecQ
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -11.45
Kyte-Doolittle Hydrophobicity Value -0.252
Molecular Weight (kDa) 79.4
Isoelectric Point (pI) 5.80

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 590 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002284 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3344
Search term: recQ

Human Homologs

Ensembl 110, assembly GRCh38.p14
BLM RecQ like helicase [Source:HGNC Symbol;Acc:HGNC:1058]
E-value: 2.3e-95
Percent Identity: 35.4
Ensembl 110, assembly GRCh38.p14
BLM RecQ like helicase [Source:HGNC Symbol;Acc:HGNC:1058]
E-value: 2.3e-95
Percent Identity: 35.4
Ensembl 110, assembly GRCh38.p14
BLM RecQ like helicase [Source:HGNC Symbol;Acc:HGNC:1058]
E-value: 2.3e-95
Percent Identity: 35.4
Ensembl 110, assembly GRCh38.p14
BLM RecQ like helicase [Source:HGNC Symbol;Acc:HGNC:1058]
E-value: 2.3e-95
Percent Identity: 35.4

References

Escherichia coli RecQ protein is a DNA helicase.
Umezu K, Nakayama K, Nakayama H
Proc Natl Acad Sci U S A 1990 Jul;87(14):5363-7
PubMed ID: 2164680
RecQ helicase and topoisomerase III comprise a novel DNA strand passage function: a conserved mechanism for control of DNA recombination.
Harmon FG, DiGate RJ, Kowalczykowski SC
Mol Cell 1999 May;3(5):611-20
PubMed ID: 10360177