Pseudomonas aeruginosa PAO1, PA3125

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3125
Name
Replicon chromosome
Genomic location 3507345 - 3508673 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs
CommentStructural similarity to 3SKV: Salicylyl-Acyltransferase SsfX3 from Streptomyces (root-mean-square deviation: 1.0 angstroms)

Cross-References

RefSeq NP_251815.1
GI 15598321
Affymetrix PA3125_at
Entrez 882639
GenBank AAG06513.1
INSDC AAG06513.1
NCBI Locus Tag PA3125
protein_id(GenBank) gb|AAG06513.1|AE004736_10|gnl|PseudoCAP|PA3125
TIGR NTL03PA03125
UniParc UPI00000C591A
UniProtKB Acc Q9HZ99
UniProtKB ID Q9HZ99_PSEAE
UniRef100 UniRef100_Q9HZ99
UniRef50 UniRef50_E1V8Y0
UniRef90 UniRef90_Q9HZ99

Product

Feature Type CDS
Coding Frame 1
Product Name
putative transferase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7) -3.61
Kyte-Doolittle Hydrophobicity Value -0.068
Molecular Weight (kDa) 46.9
Isoelectric Point (pI) 6.36

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 1
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 72 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002473 (315 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3125

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994
Uncovering the structure and function of Pseudomonas aeruginosa periplasmic proteins by an in silico approach.
Caprari S, Brandi V, Pasquadibisceglie A, Polticelli F
J Biomol Struct Dyn 2020 Sep;38(15):4508-4520
PubMed ID: 31631799