Pseudomonas aeruginosa PAO1, PA2978 (ptpA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2978
Name
ptpA
Replicon chromosome
Genomic location 3337228 - 3337692 (- strand)

Cross-References

RefSeq NP_251668.1
GI 15598174
Affymetrix PA2978_ptpA_at
Entrez 880168
GenBank AAG06366.1
INSDC AAG06366.1
NCBI Locus Tag PA2978
protein_id(GenBank) gb|AAG06366.1|AE004723_10|gnl|PseudoCAP|PA2978
TIGR NTL03PA02978
UniParc UPI00000C58B1
UniProtKB Acc Q9HZM6
UniProtKB ID Q9HZM6_PSEAE
UniRef100 UniRef100_Q9HZM6
UniRef50 UniRef50_A9AGU1
UniRef90 UniRef90_Q9HZM6

Product

Feature Type CDS
Coding Frame 1
Product Name
phosphotyrosine protein phosphatase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -2.13
Kyte-Doolittle Hydrophobicity Value -0.331
Molecular Weight (kDa) 17.2
Isoelectric Point (pI) 6.12

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 404 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002604 (507 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2978
Search term: ptpA

Human Homologs

Ensembl 110, assembly GRCh38.p14
acid phosphatase 1 [Source:HGNC Symbol;Acc:HGNC:122]
E-value: 1.7e-22
Percent Identity: 40.0

References

Cloning, purification, and properties of a phosphotyrosine protein phosphatase from Streptomyces coelicolor A3(2).
Li Y, Strohl WR
J Bacteriol 1996 Jan;178(1):136-42
PubMed ID: 8550407
Cells of Escherichia coli contain a protein-tyrosine kinase, Wzc, and a phosphotyrosine-protein phosphatase, Wzb.
Vincent C, Doublet P, Grangeasse C, Vaganay E, Cozzone AJ, Duclos B
J Bacteriol 1999 Jun;181(11):3472-7
PubMed ID: 10348860