Pseudomonas aeruginosa PAO1, PA2824 (sagS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2824
Name
sagS
Replicon chromosome
Genomic location 3177090 - 3179450 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_251514.1
GI 15598020
Affymetrix PA2824_at
Entrez 878885
GenBank AAG06212.1
INSDC AAG06212.1
NCBI Locus Tag PA2824
protein_id(GenBank) gb|AAG06212.1|AE004709_5|gnl|PseudoCAP|PA2824
TIGR NTL03PA02824
UniParc UPI00000C582A
UniProtKB Acc Q9I019
UniProtKB ID Q9I019_PSEAE
UniRef100 UniRef100_Q9I019
UniRef50 UniRef50_S6AG12
UniRef90 UniRef90_Q9I019

Product

Feature Type CDS
Coding Frame 1
Product Name
surface attachment and growth sensor hybrid, SagS
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -13.16
Kyte-Doolittle Hydrophobicity Value 0.054
Molecular Weight (kDa) 85.9
Isoelectric Point (pI) 5.65

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Cytoplasmic Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 622 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002178 (1344 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2824
Search term: sagS

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
SagS contributes to the motile-sessile switch and acts in concert with BfiSR to enable Pseudomonas aeruginosa biofilm formation.
Petrova OE, Sauer K
J Bacteriol 2011 Dec;193(23):6614-28
PubMed ID: 21949078