Pseudomonas aeruginosa BL13, Q067_00464

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas aeruginosa BL13
GCF_000480885.1|latest
Locus Tag
Q067_00464
Name
Replicon scaffold_1
Genomic location 528357 - 531497 (+ strand)

Cross-References

RefSeq WP_003109724.1
GI 489200507
NCBI Locus Tag Q067_00464

Product

Feature Type CDS
Coding Frame 1
Product Name
multidrug transporter
Synonyms
Evidence for Translation
Charge (pH 7) -10.89
Kyte-Doolittle Hydrophobicity Value 0.269
Molecular Weight (kDa) 112.8
Isoelectric Point (pI) 5.30

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
MexB MexB is the inner membrane multidrug exporter of the efflux complex MexAB-OprM. [PMID:19361527, PMID:21178960, PMID:14973037, PMID:20583998] ARO:3000378 protein homolog model Strict 1980.7 99.71 3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6IOL MEMBRANE PROTEIN 10/30/18 Cryo-EM structure of multidrug efflux pump MexAB-OprM (60 degree state) Pseudomonas aeruginosa; Pseudomonas aeruginosa PAO1 3.76 ELECTRON MICROSCOPY 99.8
6IOK MEMBRANE PROTEIN 10/30/18 Cryo-EM structure of multidrug efflux pump MexAB-OprM (0 degree state) Pseudomonas aeruginosa PAO1 3.64 ELECTRON MICROSCOPY 99.8
3W9J MEMBRANE PROTEIN 04/04/13 Structural basis for the inhibition of bacterial multidrug exporters Pseudomonas aeruginosa 3.15 X-RAY DIFFRACTION 100.0
3W9I MEMBRANE PROTEIN 04/04/13 Structural basis for the inhibition of bacterial multidrug exporters Pseudomonas aeruginosa 2.71 X-RAY DIFFRACTION 99.8
6IIA MEMBRANE PROTEIN 10/04/18 MexB in complex with LMNG Pseudomonas aeruginosa PAO1 2.91 X-RAY DIFFRACTION 100.0
2V50 MEMBRANE PROTEIN 10/01/08 The Missing Part of the Bacterial MexAB-OprM System: Structural determination of the Multidrug Exporter MexB PSEUDOMONAS AERUGINOSA PA01 3 X-RAY DIFFRACTION 100.0

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000417 (2093 members)
Putative Inparalogs 1 predicted inparalogs
RND multidrug efflux transporter MexB (Q067_02317) 67.9% identity

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: Q067_00464

Human Homologs

References

No references are associated with this feature.