Pseudomonas aeruginosa PAO1, PA2444 (glyA2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2444
Name
glyA2
Replicon chromosome
Genomic location 2742401 - 2743657 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_251134.1
GI 15597640
Affymetrix PA2444_glyA2_at
Entrez 882925
GenBank AAG05832.1
INSDC AAG05832.1
NCBI Locus Tag PA2444
protein_id(GenBank) gb|AAG05832.1|AE004671_8|gnl|PseudoCAP|PA2444
TIGR NTL03PA02444
UniParc UPI000012B4E7
UniProtKB Acc Q9I138
UniProtKB ID GLYA2_PSEAE
UniRef100 UniRef100_Q9I138
UniRef50 UniRef50_D3DKC4
UniRef90 UniRef90_Q9I138

Product

Feature Type CDS
Coding Frame 1
Product Name
serine hydroxymethyltransferase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Detected by MALDI-TOF/TOF (PMID:19333994).
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -3.78
Kyte-Doolittle Hydrophobicity Value -0.169
Molecular Weight (kDa) 45.0
Isoelectric Point (pI) 6.51

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 654 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003094 (1150 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2444
Search term: glyA2

Human Homologs

Ensembl 110, assembly GRCh38.p14
serine hydroxymethyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:10852]
E-value: 1.4e-95
Percent Identity: 43.0
Ensembl 110, assembly GRCh38.p14
serine hydroxymethyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:10852]
E-value: 1.4e-95
Percent Identity: 43.0
Ensembl 110, assembly GRCh38.p14
serine hydroxymethyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:10852]
E-value: 1.4e-95
Percent Identity: 43.0
Ensembl 110, assembly GRCh38.p14
serine hydroxymethyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:10852]
E-value: 1.4e-95
Percent Identity: 43.0

References

Characterization of the Escherichia coli gene for serine hydroxymethyltransferase.
Plamann MD, Stauffer GV
Gene 1983 Apr;22(1):9-18
PubMed ID: 6190704
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994