Pseudomonas aeruginosa PAO1, PA2129 (cupA2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2129
Name
cupA2
Replicon chromosome
Genomic location 2343132 - 2343878 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 4 transposon mutants in orthologs

Cross-References

RefSeq NP_250819.1
GI 15597325
Affymetrix PA2129_at
Entrez 877904
GenBank AAG05517.1
INSDC AAG05517.1
NCBI Locus Tag PA2129
protein_id(GenBank) gb|AAG05517.1|AE004640_6|gnl|PseudoCAP|PA2129
TIGR NTL03PA02129
UniParc UPI00000C55BF
UniProtKB Acc Q9I1Y6
UniProtKB ID Q9I1Y6_PSEAE
UniRef100 UniRef100_Q9I1Y6
UniRef50 UniRef50_Q9I1Y6
UniRef90 UniRef90_Q9I1Y6

Product

Feature Type CDS
Coding Frame 1
Product Name
chaperone CupA2
Product Name Confidence: Class 1
Synonyms component of adhesin
probable pili assembly chaperone
Evidence for Translation
Charge (pH 7) 10.67
Kyte-Doolittle Hydrophobicity Value -0.342
Molecular Weight (kDa) 27.7
Isoelectric Point (pI) 10.93

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 2
Periplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 46 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000956 (1721 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2129
Search term: cupA2
Search term: chaperone CupA2

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
The chaperone/usher pathways of Pseudomonas aeruginosa: identification of fimbrial gene clusters (cup) and their involvement in biofilm formation.
Vallet I, Olson JW, Lory S, Lazdunski A, Filloux A
Proc Natl Acad Sci U S A 2001 Jun 5;98(12):6911-6
PubMed ID: 11381121