Pseudomonas aeruginosa PAO1, PA2128 (cupA1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2128
Name
cupA1
Replicon chromosome
Genomic location 2342493 - 2343044 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 5 transposon mutants in orthologs

Cross-References

RefSeq NP_250818.1
GI 15597324
Affymetrix PA2128_at
DNASU PaCD00006942
Entrez 880862
GenBank AAG05516.1
INSDC AAG05516.1
NCBI Locus Tag PA2128
protein_id(GenBank) gb|AAG05516.1|AE004640_5|gnl|PseudoCAP|PA2128
TIGR NTL03PA02128
UniParc UPI00000D74AF
UniProtKB Acc Q9I1Y7
UniProtKB ID Q9I1Y7_PSEAE
UniRef100 UniRef100_Q9I1Y7
UniRef50 UniRef50_Q9I1Y7
UniRef90 UniRef90_Q9I1Y7

Product

Feature Type CDS
Coding Frame 1
Product Name
fimbrial subunit CupA1
Product Name Confidence: Class 1
Synonyms component of adhesin
probable fimbrial protein (precursor)
Evidence for Translation
Charge (pH 7) -11.87
Kyte-Doolittle Hydrophobicity Value 0.421
Molecular Weight (kDa) 18.2
Isoelectric Point (pI) 3.59

Subcellular localization

Individual Mappings
Localization Confidence PMID
Fimbrial
Note: This is based on PSORTb V3.0 secondary localization prediction
 Class 3
Extracellular Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 38 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000955 (1577 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2128
Search term: cupA1

Human Homologs

References

The chaperone/usher pathways of Pseudomonas aeruginosa: identification of fimbrial gene clusters (cup) and their involvement in biofilm formation.
Vallet I, Olson JW, Lory S, Lazdunski A, Filloux A
Proc Natl Acad Sci U S A 2001 Jun 5;98(12):6911-6
PubMed ID: 11381121
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Isolation and nucleotide sequence of the F17-A gene encoding the structural protein of the F17 fimbriae in bovine enterotoxigenic Escherichia coli.
Lintermans P, Pohl P, Deboeck F, Bertels A, Schlicker C, Vandekerckhove J, Van Damme J, Van Montagu M, De Greve H
Infect Immun 1988 Jun;56(6):1475-84
PubMed ID: 2897333