Pseudomonas aeruginosa PAO1, PA2121 (bsrA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2121
Name
bsrA
Replicon chromosome
Genomic location 2332968 - 2333873 (- strand)
Transposon Mutants in orthologs 4 transposon mutants in orthologs

Cross-References

RefSeq NP_250811.1
GI 15597317
Affymetrix PA2121_at
DNASU PaCD00006940
Entrez 878089
GenBank AAG05509.1
INSDC AAG05509.1
NCBI Locus Tag PA2121
protein_id(GenBank) gb|AAG05509.1|AE004639_7|gnl|PseudoCAP|PA2121
TIGR NTL03PA02121
UniParc UPI00000C55B8
UniProtKB Acc Q9I1Z4
UniProtKB ID Q9I1Z4_PSEAE
UniRef100 UniRef100_Q9I1Z4
UniRef50 UniRef50_Q4KAE4
UniRef90 UniRef90_Q9I1Z4

Product

Feature Type CDS
Coding Frame 1
Product Name
LysR-type transcriptional regulator, BsrA
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 4.92
Kyte-Doolittle Hydrophobicity Value -0.072
Molecular Weight (kDa) 33.5
Isoelectric Point (pI) 9.65

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 2
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 373 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001179 (1943 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2121
Search term: bsrA

Human Homologs

References

The LysR-Type Transcriptional Regulator BsrA (PA2121) Controls Vital Metabolic Pathways in Pseudomonas aeruginosa.
Modrzejewska M, Kawalek A, Bartosik AA
mSystems 2021 Aug 31;6(4):e0001521
PubMed ID: 34254827
A putative LysR-type transcriptional regulator inhibits biofilm synthesis in Pseudomonas aeruginosa.
Yang X, Zhang Z, Huang Z, Zhang X, Li D, Sun L, You J, Pan X, Yang H
Biofouling 2019 May;35(5):541-550
PubMed ID: 31269803