Pseudomonas aeruginosa PAO1, PA2113 (opdO)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2113
Name
opdO
Synonym: opdO
Replicon chromosome
Genomic location 2323554 - 2324783 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250803.1
GI 15597309
Affymetrix PA2113_at
Entrez 879972
GenBank AAG05501.1
INSDC AAG05501.1
NCBI Locus Tag PA2113
protein_id(GenBank) gb|AAG05501.1|AE004638_11|gnl|PseudoCAP|PA2113
TIGR NTL03PA02113
UniParc UPI00000C55B0
UniProtKB Acc Q9I202
UniProtKB ID Q9I202_PSEAE
UniRef100 UniRef100_Q9I202
UniRef50 UniRef50_W6QYC2
UniRef90 UniRef90_Q9I202

Product

Feature Type CDS
Coding Frame 1
Product Name
pyroglutamate porin OpdO
Product Name Confidence: Class 1
Synonyms OccK3
pyroglutatmate porin OpdO
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -4.31
Kyte-Doolittle Hydrophobicity Value -0.260
Molecular Weight (kDa) 44.3
Isoelectric Point (pI) 5.94

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 2
Outer Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2Y0K TRANSPORT PROTEIN 12/03/10 Crystal Structure of Pseudomonas Aeruginosa OpdO PSEUDOMONAS AERUGINOSA 2.295 X-RAY DIFFRACTION 100.0
3SZV MEMBRANE PROTEIN 07/19/11 Crystal structure of Pseudomonas aeruginosa OccK3 (OpdO) Pseudomonas aeruginosa 1.45 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 25 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003356 (323 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2113
Search term: opdO

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Responses of carbapenemase-producing and non-producing carbapenem-resistant Pseudomonas aeruginosa strains to meropenem revealed by quantitative tandem mass spectrometry proteomics.
Salvà-Serra F, Jaén-Luchoro D, Marathe NP, Adlerberth I, Moore ERB, Karlsson R
Front Microbiol 2022;13:1089140
PubMed ID: 36845973
Role of the novel OprD family of porins in nutrient uptake in Pseudomonas aeruginosa.
Tamber S, Ochs MM, Hancock RE
J Bacteriol 2006 Jan;188(1):45-54
PubMed ID: 16352820
Substrate specificity within a family of outer membrane carboxylate channels.
Eren E, Vijayaraghavan J, Liu J, Cheneke BR, Touw DS, Lepore BW, Indic M, Movileanu L, van den Berg B
PLoS Biol 2012 Jan;10(1):e1001242
PubMed ID: 22272184
OccK channels from Pseudomonas aeruginosa exhibit diverse single-channel electrical signatures but conserved anion selectivity.
Liu J, Eren E, Vijayaraghavan J, Cheneke BR, Indic M, van den Berg B, Movileanu L
Biochemistry 2012 Mar 20;51(11):2319-30
PubMed ID: 22369314