Pseudomonas aeruginosa PAO1, PA1900 (phzB2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1900
Name
phzB2
Replicon chromosome
Genomic location 2071209 - 2071697 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250591.1
GI 15597097
Entrez 878211
GenBank AAG05289.1
INSDC AAG05289.1
NCBI Locus Tag PA1900
protein_id(GenBank) gb|AAG05289.1|AE004616_3|gnl|PseudoCAP|PA1900
TIGR NTL03PA01901
UniParc UPI00000D423E
UniProtKB Acc Q9S508
UniProtKB ID PHZB2_PSEAE
UniRef100 UniRef100_Q02L47
UniRef50 UniRef50_Q02L47
UniRef90 UniRef90_Q02L47

Product

Feature Type CDS
Coding Frame 1
Product Name
probable phenazine biosynthesis protein
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -2.65
Kyte-Doolittle Hydrophobicity Value -0.670
Molecular Weight (kDa) 19.0
Isoelectric Point (pI) 6.24

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 1
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3FF0 BIOSYNTHETIC PROTEIN 12/01/08 Crystal structure of a phenazine biosynthesis-related protein (phzb2) from pseudomonas aeruginosa at 1.90 A resolution Pseudomonas aeruginosa 1.9 X-RAY DIFFRACTION 100.0

Virulence Evidence

Source 1
Database VFDB
Category Phenazine biosynthesis
Evidence
Host Organism
Notes
Reference

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 6 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003512 (231 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1900
Search term: phzB2

Human Homologs

References

Functional analysis of genes for biosynthesis of pyocyanin and phenazine-1-carboxamide from Pseudomonas aeruginosa PAO1.
Mavrodi DV, Bonsall RF, Delaney SM, Soule MJ, Phillips G, Thomashow LS
J Bacteriol 2001 Nov;183(21):6454-65
PubMed ID: 11591691
Molecular analysis of genes encoding phenazine biosynthesis in the biological control bacterium. Pseudomonas aureofaciens 30-84.
Pierson LS 3rd, Gaffney T, Lam S, Gong F
FEMS Microbiol Lett 1995 Dec 15;134(2-3):299-307
PubMed ID: 8586283