Pseudomonas aeruginosa PAO1, PA1847 (nfuA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1847
Name
nfuA
Synonym: yhgI
Replicon chromosome
Genomic location 2007665 - 2008249 (+ strand)
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250538.1
GI 15597044
Affymetrix PA1847_at
DNASU PaCD00006835
Entrez 880675
GenBank AAG05236.1
INSDC AAG05236.1
NCBI Locus Tag PA1847
protein_id(GenBank) gb|AAG05236.1|AE004611_1|gnl|PseudoCAP|PA1847
TIGR NTL03PA01848
UniParc UPI00000C54CB
UniProtKB Acc Q9I2P8
UniProtKB ID NFUA_PSEAE
UniRef100 UniRef100_A6V6X0
UniRef50 UniRef50_Q4KAH1
UniRef90 UniRef90_A6V6X0

Product

Feature Type CDS
Coding Frame 1
Product Name
NfuA
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -13.64
Kyte-Doolittle Hydrophobicity Value -0.158
Molecular Weight (kDa) 21.1
Isoelectric Point (pI) 4.20

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 324 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003553 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1847
Search term: nfuA
Search term: NfuA

Human Homologs

References

Inactivation of nfuA enhances susceptibility of Pseudomonas aeruginosa to fluoroquinolone antibiotics.
Daung-nkern J, Vattanaviboon P, Mongkolsuk S
J Antimicrob Chemother 2010 Aug;65(8):1831-2
PubMed ID: 20525732