Pseudomonas aeruginosa PAO1, PA1618

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1618
Name
Synonym: ybdB
Replicon chromosome
Genomic location 1762433 - 1762870 (+ strand)

Cross-References

RefSeq NP_250309.1
GI 15596815
Affymetrix PA1618_at
Entrez 881899
GenBank AAG05007.1
INSDC AAG05007.1
NCBI Locus Tag PA1618
protein_id(GenBank) gb|AAG05007.1|AE004589_10|gnl|PseudoCAP|PA1618
TIGR NTL03PA01619
UniParc UPI000013AF24
UniProtKB Acc Q9I3A4
UniProtKB ID Y1618_PSEAE
UniRef100 UniRef100_Q9I3A4
UniRef50 UniRef50_Q9I3A4
UniRef90 UniRef90_Q9I3A4

Product

Feature Type CDS
Coding Frame 1
Product Name
thiolester hydrolase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 0.10
Kyte-Doolittle Hydrophobicity Value -0.028
Molecular Weight (kDa) 15.6
Isoelectric Point (pI) 7.04

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4QDA HYDROLASE 05/13/14 Crystal structure of mutant Thioesterase PA1618 (E64A) from Pseudomonas aeruginosa Pseudomonas aeruginosa 2.299 X-RAY DIFFRACTION 99.3
4QD9 HYDROLASE 05/13/14 Crystal structure of Thioesterase PA1618 from Pseudomonas aeruginosa in complex with benzoyl-dO-CoA Pseudomonas aeruginosa 1.767 X-RAY DIFFRACTION 100.0
4QD7 HYDROLASE 05/13/14 Crystal structure of Thioesterase PA1618 from Pseudomonas aeruginosa Pseudomonas aeruginosa 1.765 X-RAY DIFFRACTION 100.0
4QDB HYDROLASE 05/13/14 Crystal structure of mutant Thioesterase PA1618 (Q49A) from Pseudomonas aeruginosa Pseudomonas aeruginosa 2.023 X-RAY DIFFRACTION 99.3
4QD8 HYDROLASE 05/13/14 Crystal structure of Thioesterase PA1618 from Pseudomonas aeruginosa in complex with phenacyl-CoA Pseudomonas aeruginosa 1.616 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 249 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003752 (485 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1618

Human Homologs

References

Catalytic Mechanism of the Hotdog-Fold Thioesterase PA1618 Revealed by X-ray Structure Determination of a Substrate-Bound Oxygen Ester Analogue Complex.
Latham JA, Ji T, Matthews K, Mariano PS, Allen KN, Dunaway-Mariano D
Chembiochem 2017 Oct 5;18(19):1935-1943
PubMed ID: 28741300