Pseudomonas aeruginosa PAO1, PA1614 (gpsA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1614
Name
gpsA
Synonym: gpdA
Replicon chromosome
Genomic location 1758748 - 1759770 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_250305.1
GI 15596811
Affymetrix PA1614_gpsA_at
DNASU PaCD00006737
Entrez 881904
GenBank AAG05003.1
INSDC AAG05003.1
NCBI Locus Tag PA1614
protein_id(GenBank) gb|AAG05003.1|AE004589_6|gnl|PseudoCAP|PA1614
TIGR NTL03PA01615
UniParc UPI000012B996
UniProtKB Acc Q9I3A8
UniProtKB ID GPDA_PSEAE
UniRef100 UniRef100_Q02K99
UniRef50 UniRef50_Q4KFW6
UniRef90 UniRef90_Q02K99

Product

Feature Type CDS
Coding Frame 1
Product Name
glycerol-3-phosphate dehydrogenase, biosynthetic
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -3.40
Kyte-Doolittle Hydrophobicity Value 0.024
Molecular Weight (kDa) 36.8
Isoelectric Point (pI) 6.18

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 573 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003756 (537 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1614
Search term: gpsA

Human Homologs

References

Regulation of phospholipid biosynthesis in Escherichia coli. Cloning of the structural gene for the biosynthetic sn-glycerol-3-phosphate dehydrogenase.
Clark D, Lightner V, Edgar R, Modrich P, Cronan JE Jr, Bell RM
J Biol Chem 1980 Jan 25;255(2):714-7
PubMed ID: 6985897
Synthesis of sn-glycerol 3-phosphate, a key precursor of membrane lipids, in Bacillus subtilis.
Morbidoni HR, de Mendoza D, Cronan JE Jr
J Bacteriol 1995 Oct;177(20):5899-905
PubMed ID: 7592341