Pseudomonas aeruginosa PAO1, PA1556 (ccoO2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1556
Name
ccoO2
Synonym: ccoO
Synonym: fixO
Replicon chromosome
Genomic location 1694233 - 1694841 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_250247.1
GI 15596753
Affymetrix PA1556_at
Entrez 883049
GenBank AAG04945.1
INSDC AAG04945.1
NCBI Locus Tag PA1556
protein_id(GenBank) gb|AAG04945.1|AE004584_1|gnl|PseudoCAP|PA1556
TIGR NTL03PA01557
UniParc UPI00000C53DA
UniProtKB Acc Q9I3G1
UniProtKB ID Q9I3G1_PSEAE
UniRef100 UniRef100_W0YQ45
UniRef50 UniRef50_A4G5L4
UniRef90 UniRef90_M4XHY7

Product

Feature Type CDS
Coding Frame 1
Product Name
Cytochrome c oxidase, cbb3-type, CcoO subunit
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Detected using LC-MS/MS (22.78 kDa, PMID:21751344)
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 2.34
Kyte-Doolittle Hydrophobicity Value -0.365
Molecular Weight (kDa) 22.8
Isoelectric Point (pI) 8.08

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Outer Membrane Vesicle Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 217 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003806 (921 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1556
Search term: ccoO2

Human Homologs

References

Functional and regulatory analysis of the two copies of the fixNOQP operon of Rhizobium leguminosarum strain VF39.
Schlüter A, Patschkowski T, Quandt J, Selinger LB, Weidner S, Krämer M, Zhou L, Hynes MF, Priefer UB
Mol Plant Microbe Interact 1997 Jul;10(5):605-16
PubMed ID: 9204566
Isolation and characterization of Rhodobacter capsulatus mutants affected in cytochrome cbb3 oxidase activity.
Koch HG, Hwang O, Daldal F
J Bacteriol 1998 Feb;180(4):969-78
PubMed ID: 9473054
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344