Pseudomonas aeruginosa PAO1, PA1555 (ccoP2)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1555
Name
ccoP2
Synonym: ccoP
Synonym: fixP
Replicon chromosome
Genomic location 1693119 - 1694045 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq NP_250246.1
GI 15596752
Affymetrix PA1555_at
DNASU PaCD00006711
Entrez 883066
GenBank AAG04944.1
INSDC AAG04944.1
NCBI Locus Tag PA1555
protein_id(GenBank) gb|AAG04944.1|AE004583_9|gnl|PseudoCAP|PA1555
TIGR NTL03PA01556
UniParc UPI00000C53D9
UniProtKB Acc Q9I3G2
UniProtKB ID Q9I3G2_PSEAE
UniRef100 UniRef100_W0YNF4
UniRef50 UniRef50_D9IA45
UniRef90 UniRef90_A6V7U5

Product

Feature Type CDS
Coding Frame 1
Product Name
Cytochrome c oxidase, cbb3-type, CcoP subunit
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Detected using LC-MS/MS (33.81 kDa, PMID:21751344)
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -2.21
Kyte-Doolittle Hydrophobicity Value -0.207
Molecular Weight (kDa) 33.8
Isoelectric Point (pI) 6.51

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Outer Membrane Vesicle Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 213 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003807 (889 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1555
Search term: ccoP2

Human Homologs

References

Genes for a microaerobically induced oxidase complex in Bradyrhizobium japonicum are essential for a nitrogen-fixing endosymbiosis.
Preisig O, Anthamatten D, Hennecke H
Proc Natl Acad Sci U S A 1993 Apr 15;90(8):3309-13
PubMed ID: 8386371
Structural and functional analysis of aa3-type and cbb3-type cytochrome c oxidases of Paracoccus denitrificans reveals significant differences in proton-pump design.
de Gier JW, Schepper M, Reijnders WN, van Dyck SJ, Slotboom DJ, Warne A, Saraste M, Krab K, Finel M, Stouthamer AH, van Spanning RJ, van der Oost J
Mol Microbiol 1996 Jun;20(6):1247-60
PubMed ID: 8809776
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344