Pseudomonas aeruginosa PAO1, PA1552 (ccoP1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1552
Name
ccoP1
Replicon chromosome
Genomic location 1689557 - 1690513 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq NP_250243.1
GI 15596749
Affymetrix PA1552_at
DNASU PaCD00006709
Entrez 883043
GenBank AAG04941.1
INSDC AAG04941.1
NCBI Locus Tag PA1552
protein_id(GenBank) gb|AAG04941.1|AE004583_6|gnl|PseudoCAP|PA1552
TIGR NTL03PA01553
UniParc UPI00000C53D6
UniProtKB Acc Q9I3G5
UniProtKB ID Q9I3G5_PSEAE
UniRef100 UniRef100_Q9I3G5
UniRef50 UniRef50_Q9I3G5
UniRef90 UniRef90_Q9I3G5

Product

Feature Type CDS
Coding Frame 1
Product Name
Cytochrome c oxidase, cbb3-type, CcoP subunit
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Detected using LC-MS/MS (34.64 kDa, PMID:21751344)
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -4.96
Kyte-Doolittle Hydrophobicity Value -0.211
Molecular Weight (kDa) 34.6
Isoelectric Point (pI) 6.04

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Outer Membrane Vesicle Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 212 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003807 (889 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1552
Search term: ccoP1

Human Homologs

References

Genes for a microaerobically induced oxidase complex in Bradyrhizobium japonicum are essential for a nitrogen-fixing endosymbiosis.
Preisig O, Anthamatten D, Hennecke H
Proc Natl Acad Sci U S A 1993 Apr 15;90(8):3309-13
PubMed ID: 8386371
Structural and functional analysis of aa3-type and cbb3-type cytochrome c oxidases of Paracoccus denitrificans reveals significant differences in proton-pump design.
de Gier JW, Schepper M, Reijnders WN, van Dyck SJ, Slotboom DJ, Warne A, Saraste M, Krab K, Finel M, Stouthamer AH, van Spanning RJ, van der Oost J
Mol Microbiol 1996 Jun;20(6):1247-60
PubMed ID: 8809776
Differences in two Pseudomonas aeruginosa cbb3 cytochrome oxidases.
Comolli JC, Donohue TJ
Mol Microbiol 2004 Feb;51(4):1193-203
PubMed ID: 14763990
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344