Pseudomonas aeruginosa PAO1, PA1528 (zipA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1528
Name
zipA
Replicon chromosome
Genomic location 1665065 - 1665934 (+ strand)
Transposon Mutants 1 transposon mutants in PAO1

Cross-References

RefSeq NP_250219.1
GI 15596725
Affymetrix PA1528_zipA_at
Entrez 879535
GenBank AAG04917.1
INSDC AAG04917.1
NCBI Locus Tag PA1528
protein_id(GenBank) gb|AAG04917.1|AE004581_4|gnl|PseudoCAP|PA1528
TIGR NTL03PA01529
UniParc UPI000013C3E7
UniProtKB Acc Q9I3I5
UniProtKB ID ZIPA_PSEAE
UniRef100 UniRef100_B7UVJ4
UniRef50 UniRef50_Q87YY5
UniRef90 UniRef90_B7UVJ4

Product

Feature Type CDS
Coding Frame 1
Product Name
cell division protein ZipA
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Detected using LC-MS/MS (32.24 kDa, PMID:21751344)
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -5.29
Kyte-Doolittle Hydrophobicity Value -0.569
Molecular Weight (kDa) 32.2
Isoelectric Point (pI) 5.72

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Outer Membrane Vesicle Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 97 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003830 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1528
Search term: zipA

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Direct binding of FtsZ to ZipA, an essential component of the septal ring structure that mediates cell division in E. coli.
Hale CA, de Boer PA
Cell 1997 Jan 24;88(2):175-85
PubMed ID: 9008158
Recruitment of ZipA to the division site by interaction with FtsZ.
Liu Z, Mukherjee A, Lutkenhaus J
Mol Microbiol 1999 Mar;31(6):1853-61
PubMed ID: 10209756
Proteomic analysis of outer membrane vesicles derived from Pseudomonas aeruginosa.
Choi DS, Kim DK, Choi SJ, Lee J, Choi JP, Rho S, Park SH, Kim YK, Hwang D, Gho YS
Proteomics 2011 Aug;11(16):3424-9
PubMed ID: 21751344