Pseudomonas thermotolerans J53, M905_RS0100920

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown

Gene Feature Overview

Strain Pseudomonas thermotolerans J53
GCF_000513835.1|latest
Locus Tag
M905_RS0100920
Name
Replicon scaffold_0.1_C
Genomic location 193665 - 194576 (- strand)

Cross-References

RefSeq WP_027895998.1
GI 654424788
NCBI Locus Tag M905_RS0100920

Product

Feature Type CDS
Coding Frame 1
Product Name
UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase
Synonyms
Evidence for Translation
Charge (pH 7) -6.55
Kyte-Doolittle Hydrophobicity Value -0.093
Molecular Weight (kDa) 33.5
Isoelectric Point (pI) 5.26

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4FW6 Hydrolase/Hydrolase Inhibitor 06/29/12 Crystal Structure of the LpxC in complex with N-[(2S,3R)-3-HYDROXY-1-(HYDROXYAMINO)-1-OXOBUTAN-2-YL]-4-(PHENYLETHYNYL)BENZAMIDE inhibitor Pseudomonas aeruginosa 1.83 X-RAY DIFFRACTION 92.0
6E54 hydrolase/hydrolase inhibitor 07/19/18 Crystal structure of LpxC from Pseudomonas aeruginosa in complex with ligand PT802 Pseudomonas aeruginosa 1.65 X-RAY DIFFRACTION 91.7
6C9C hydrolase/hydrolase inhibitor 01/26/18 Crystal structure of LpxC from Pseudomonas aeruginosa in complex with racemic ligand PT803 Pseudomonas aeruginosa (strain UCBPP-PA14) 2 X-RAY DIFFRACTION 91.7
4FW7 HYDROLASE/HYDROLASE INHIBITOR 06/30/12 Crystal Structure of the LpxC in complex with N-[(2S,3R)-3-HYDROXY-1-(HYDROXYAMINO)-1-OXOBUTAN-2-YL]BIPHENYL-4-CARBOXAMIDE inhibitor Pseudomonas aeruginosa 1.7 X-RAY DIFFRACTION 92.0
4OKG HYDROLASE/HYDROLASE INHIBITOR 01/22/14 LpxC from P.aeruginosa with the inhibitor 6-(benzimidazol-1-yl)-5-[4-[2-[6-[(4-methylpiperazin-1-yl)methyl]-3-pyridyl]ethynyl]phenyl]pyridine-3-carbohydroxamic acid Pseudomonas aeruginosa 2.06 X-RAY DIFFRACTION 92.0
4LCH HYDROLASE/ANTIBIOTIC 06/21/13 Crystal structure of the Pseudomonas aeruginosa LPXC/LPC-051 complex Pseudomonas aeruginosa 1.596 X-RAY DIFFRACTION 92.0
7CIB HYDROLASE 07/07/20 Crystal structure of P.aeruginosa LpxC in complex with inhibitor Pseudomonas aeruginosa PAO1 1.61 X-RAY DIFFRACTION 92.0
5N8C HYDROLASE 02/23/17 Crystal structure of Pseudomonas aeruginosa LpxC complexed with inhibitor Pseudomonas aeruginosa 1.9 X-RAY DIFFRACTION 91.7
7CI8 HYDROLASE 07/07/20 Crystal structure of P.aeruginosa LpxC in complex with inhibitor Pseudomonas aeruginosa PAO1 3 X-RAY DIFFRACTION 92.0
7K99 HYDROLASE 09/28/20 Crystal Structure of P. aeruginosa LpxC with N-Hydroxyformamide inhibitor 19 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 1.9 X-RAY DIFFRACTION 91.7
6DUI hydrolase/hydrolase inhibitor 06/20/18 Crystal structure of LpxC from Pseudomonas aeruginosa in complex with PT801 Pseudomonas aeruginosa (strain LESB58) 1.55 X-RAY DIFFRACTION 91.7
7CID HYDROLASE 07/07/20 Crystal structure of P.aeruginosa LpxC in complex with inhibitor Pseudomonas aeruginosa PAO1 2.49 X-RAY DIFFRACTION 92.0
6CAX hydrolase/hydrolase inhibitor 02/01/18 Crystal structure of LpxC from Pseudomonas aeruginosa in complex with PT805 Pseudomonas aeruginosa 1.25 X-RAY DIFFRACTION 91.7
7CIA HYDROLASE 07/07/20 Crystal structure of P.aeruginosa LpxC in complex with inhibitor Pseudomonas aeruginosa PAO1 1.92 X-RAY DIFFRACTION 92.0
7CIC HYDROLASE 07/07/20 Crystal structure of P.aeruginosa LpxC in complex with inhibitor Pseudomonas aeruginosa PAO1 1.78 X-RAY DIFFRACTION 92.0
7CI9 HYDROLASE 07/07/20 Crystal structure of P.aeruginosa LpxC in complex with inhibitor Pseudomonas aeruginosa PAO1 1.9 X-RAY DIFFRACTION 92.0
7K9A HYDROLASE 09/29/20 Crystal Structure of P. aeruginosa LpxC with N-Hydroxyformamide inhibitor Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2 X-RAY DIFFRACTION 91.7
5UPG HYDROLASE 02/02/17 Crystal structure of LpxC from Pseudomonas aeruginosa in complex with PF-5081090 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 1.7 X-RAY DIFFRACTION 91.7
5VWM Hydrolase/Hydrolase Inhibitor 05/22/17 Crystal structure of UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) from Pseudomonas aeruginosa in complex with CHIR-090 inhibitor Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 1.8 X-RAY DIFFRACTION 91.7
7CIE HYDROLASE 07/07/20 Crystal structure of P.aeruginosa LpxC in complex with inhibitor Pseudomonas aeruginosa PAO1 2.15 X-RAY DIFFRACTION 92.0

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003996 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: M905_RS0100920

Human Homologs

References

No references are associated with this feature.