Pseudomonas aeruginosa PAO1, PA4724

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4724
Name
Synonym: yadB
Replicon chromosome
Genomic location 5302900 - 5303781 (+ strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253412.1
GI 15599918
Affymetrix PA4724_at
Entrez 881601
GenBank AAG08110.1
INSDC AAG08110.1
NCBI Locus Tag PA4724
protein_id(GenBank) gb|AAG08110.1|AE004886_2|gnl|PseudoCAP|PA4724
TIGR NTL03PA04725
UniParc UPI00000D42BF
UniProtKB Acc Q9HV75
UniProtKB ID GLUQ_PSEAE
UniRef100 UniRef100_Q9HV75
UniRef50 UniRef50_Q9HV75
UniRef90 UniRef90_Q9HV75

Product

Feature Type CDS
Coding Frame 1
Product Name
probable aminoacyl-transfer RNA synthetase (class I)
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.68
Kyte-Doolittle Hydrophobicity Value -0.239
Molecular Weight (kDa) 32.5
Isoelectric Point (pI) 6.52

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 664 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004370 (531 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4724

Human Homologs

Ensembl 110, assembly GRCh38.p14
glutamyl-tRNA synthetase 2, mitochondrial [Source:HGNC Symbol;Acc:HGNC:29419]
E-value: 8.0e-34
Percent Identity: 35.9
Ensembl 110, assembly GRCh38.p14
glutamyl-tRNA synthetase 2, mitochondrial [Source:HGNC Symbol;Acc:HGNC:29419]
E-value: 8.0e-34
Percent Identity: 35.9
Ensembl 110, assembly GRCh38.p14
glutamyl-tRNA synthetase 2, mitochondrial [Source:HGNC Symbol;Acc:HGNC:29419]
E-value: 8.0e-34
Percent Identity: 35.9
Ensembl 110, assembly GRCh38.p14
glutamyl-tRNA synthetase 2, mitochondrial [Source:HGNC Symbol;Acc:HGNC:29419]
E-value: 8.0e-34
Percent Identity: 35.9

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295