Pseudomonas aeruginosa PAO1, PA1799 (parR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA1799
Name
parR
Replicon chromosome
Genomic location 1951726 - 1952433 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_250490.1
GI 15596996
Affymetrix PA1799_at
DNASU PaCD00006819
Entrez 878354
GenBank AAG05188.1
INSDC AAG05188.1
NCBI Locus Tag PA1799
protein_id(GenBank) gb|AAG05188.1|AE004606_2|gnl|PseudoCAP|PA1799
TIGR NTL03PA01800
UniParc UPI00000C54A3
UniProtKB Acc Q9I2U3
UniProtKB ID Q9I2U3_PSEAE
UniRef100 UniRef100_W0YP40
UniRef50 UniRef50_Q4KDD9
UniRef90 UniRef90_A6V721

Product

Feature Type CDS
Coding Frame 1
Product Name
two-component response regulator, ParR
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -2.12
Kyte-Doolittle Hydrophobicity Value -0.058
Molecular Weight (kDa) 26.5
Isoelectric Point (pI) 6.15

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Cytoplasmic Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
ParR ParR is a component of the two-component sensor ParRS. Alongside its counterpart ParS, it confers resistance to polycationic antibiotics through the regulation of efflux components and porins. [PMID:15608211, PMID:10984043, PMID:18978025, PMID:21149619] ARO:3005068 protein homolog model Perfect 471.9 100.0 3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 622 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003598 (421 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA1799
Search term: parR

Human Homologs

References

In vivo characterization of tus gene expression in Escherichia coli.
Roecklein BA, Kuempel PL
Mol Microbiol 1992 Jun;6(12):1655-61
PubMed ID: 1495392
Adaptive resistance to the "last hope" antibiotics polymyxin B and colistin in Pseudomonas aeruginosa is mediated by the novel two-component regulatory system ParR-ParS.
Fernández L, Gooderham WJ, Bains M, McPhee JB, Wiegand I, Hancock RE
Antimicrob Agents Chemother 2010 Aug;54(8):3372-82
PubMed ID: 20547815