Pseudomonas aeruginosa UCBPP-PA14, PA14_29740 (bqsS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_29740
Name
bqsS
Synonym: carS
Replicon chromosome
Genomic location 2574563 - 2575900 (+ strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 2 transposon mutants in orthologs
CommentFirst described as BqsS in PMID:19513205 (2008). Later referred to as CarS in PMID:26755627 (2016). According to pseudomonas.com guidelines, earlier gene name takes precedence if it appeared in a peer-reviewed scientific publication.

Cross-References

RefSeq YP_790538.1
GI 116050643
Entrez 4380687
INSDC ABJ11879.1
NCBI Locus Tag PA14_29740
UniParc UPI0000395E6B
UniProtKB Acc Q02NE8
UniProtKB ID Q02NE8_PSEAB
UniRef100 UniRef100_Q02NE8
UniRef50 UniRef50_C1DL27
UniRef90 UniRef90_A0A086BZ01

Product

Feature Type CDS
Coding Frame 1
Product Name
two-component sensor BqsS
Product Name Confidence: Class 1
Synonyms two-component sensor
Evidence for Translation
Charge (pH 7) -0.93
Kyte-Doolittle Hydrophobicity Value -0.249
Molecular Weight (kDa) 49.8
Isoelectric Point (pI) 6.80

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database PseudoCAP
Category
Evidence ECO:0000314
direct assay evidence used in manual assertion
Host Organism Danio rerio
Notes
Infection model Zebrafish embryo survival
Reference 21971182

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 595 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002901 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_29740
Search term: bqsS

Human Homologs

References

A novel two-component system BqsS-BqsR modulates quorum sensing-dependent biofilm decay in Pseudomonas aeruginosa.
Dong YH, Zhang XF, An SW, Xu JL, Zhang LH
Commun Integr Biol 2008;1(1):88-96
PubMed ID: 19513205
The ferrous iron-responsive BqsRS two-component system activates genes that promote cationic stress tolerance.
Kreamer NN, Costa F, Newman DK
mBio 2015 Feb 24;6(2):e02549
PubMed ID: 25714721
BqsR/BqsS constitute a two-component system that senses extracellular Fe(II) in Pseudomonas aeruginosa.
Kreamer NN, Wilks JC, Marlow JJ, Coleman ML, Newman DK
J Bacteriol 2012 Mar;194(5):1195-204
PubMed ID: 22194456