Pseudomonas fluorescens SBW25, PFLU2662 (metH)
Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
Gene Ontology
| Ontology | Accession | Term | GO Evidence | Evidence Ontology (ECO) Code | Reference | Comments |
|---|---|---|---|---|---|---|
| Biological Process | GO:0042558 | pteridine-containing compound metabolic process |
Inferred from Sequence Model
Term mapped from: InterPro:PF00809
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Biological Process | GO:0009086 | methionine biosynthetic process |
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000381
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Biological Process | GO:0044237 | cellular metabolic process |
Inferred from Sequence Model
Term mapped from: InterPro:SSF51717
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0031419 | cobalamin binding |
Inferred from Sequence Model
Term mapped from: InterPro:cd02069
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0008270 | zinc ion binding |
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000381
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0046872 | metal ion binding |
Inferred from Sequence Model
Term mapped from: InterPro:PF02310
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
||
| Molecular Function | GO:0008705 | methionine synthase activity |
Inferred from Sequence Model
Term mapped from: InterPro:PIRSF000381
|
ECO:0000259 match to InterPro signature evidence used in automatic assertion |
Functional Classifications Manually Assigned by PseudoCAP
|
|
Pathways
| Database | Xref | Pathway | Version | Evidence | PMID |
|---|---|---|---|---|---|
| KEGG (InterPro) | 00450 | Selenocompound metabolism | InterPro 5.8-49.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
0 |
| KEGG (InterPro) | 00670 | One carbon pool by folate | InterPro 5.8-49.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
0 |
| UniPathway | UPA00051 | L-methionine biosynthesis via de novo pathway | InterPro 5.8-49.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
0 |
| KEGG (InterPro) | 00270 | Cysteine and methionine metabolism | InterPro 5.8-49.0 |
ECO:0000259
match to InterPro signature evidence used in automatic assertion |
0 |
Functional Predictions from Interpro
| Analysis | Accession | Description | Interpro Accession | Interpro Description | Amino Acid Start | Amino Acid Stop | E-value |
|---|---|---|---|---|---|---|---|
| PIRSF | PIRSF000381 | Met_synth_MetH | IPR011822 | Cobalamin-dependent methionine synthase | 4 | 1205 | 0.0 |
| FunFam | G3DSA:3.20.20.330:FF:000001 | Methionine synthase | - | - | 5 | 341 | 0.0 |
| Gene3D | G3DSA:3.20.20.330 | - | IPR036589 | Homocysteine-binding domain superfamily | 5 | 341 | 3.4E-122 |
| PANTHER | PTHR45833 | METHIONINE SYNTHASE | - | - | 9 | 1234 | 0.0 |
| SUPERFAMILY | SSF82282 | Homocysteine S-methyltransferase | IPR036589 | Homocysteine-binding domain superfamily | 11 | 402 | 7.06E-116 |
| NCBIfam | TIGR02082 | JCVI: methionine synthase | IPR011822 | Cobalamin-dependent methionine synthase | 15 | 1202 | 0.0 |
| Pfam | PF02574 | Homocysteine S-methyltransferase | IPR003726 | Homocysteine-binding domain | 20 | 328 | 4.1E-78 |
| FunFam | G3DSA:3.20.20.20:FF:000002 | Methionine synthase | - | - | 349 | 645 | 0.0 |
| Gene3D | G3DSA:3.20.20.20 | - | IPR011005 | Dihydropteroate synthase-like | 349 | 645 | 0.0 |
| CDD | cd00740 | MeTr | - | - | 359 | 615 | 4.51627E-124 |
| SUPERFAMILY | SSF51717 | Dihydropteroate synthetase-like | IPR011005 | Dihydropteroate synthase-like | 359 | 632 | 4.71E-88 |
| Pfam | PF00809 | Pterin binding enzyme | IPR000489 | Pterin-binding domain | 363 | 601 | 2.6E-56 |
| Gene3D | G3DSA:1.10.1240.10 | Methionine synthase domain | IPR036594 | Methionine synthase domain | 646 | 739 | 1.6E-37 |
| FunFam | G3DSA:1.10.1240.10:FF:000001 | Methionine synthase | - | - | 647 | 741 | 3.2E-44 |
| SUPERFAMILY | SSF47644 | Methionine synthase domain | IPR036594 | Methionine synthase domain | 653 | 739 | 4.32E-27 |
| SMART | SM01018 | B12_binding_2_2 | IPR003759 | Cobalamin (vitamin B12)-binding module, cap domain | 658 | 741 | 9.9E-42 |
| CDD | cd02069 | methionine_synthase_B12_BD | IPR033706 | Methionine synthase, B12-binding domain | 660 | 874 | 3.71142E-125 |
| Pfam | PF02607 | B12 binding domain | IPR003759 | Cobalamin (vitamin B12)-binding module, cap domain | 661 | 733 | 7.8E-24 |
| SUPERFAMILY | SSF52242 | Cobalamin (vitamin B12)-binding domain | IPR036724 | Cobalamin-binding domain superfamily | 744 | 896 | 2.35E-44 |
| FunFam | G3DSA:3.40.50.280:FF:000001 | Methionine synthase | - | - | 746 | 898 | 1.0E-77 |
| Gene3D | G3DSA:3.40.50.280 | - | - | - | 746 | 898 | 1.4E-56 |
| Pfam | PF02310 | B12 binding domain | IPR006158 | Cobalamin (vitamin B12)-binding domain | 750 | 843 | 4.8E-18 |
| SUPERFAMILY | SSF56507 | Methionine synthase activation domain-like | IPR037010 | Vitamin B12-dependent methionine synthase, activation domain superfamily | 905 | 1235 | 6.54E-123 |
| Gene3D | G3DSA:3.10.196.10 | - | IPR037010 | Vitamin B12-dependent methionine synthase, activation domain superfamily | 910 | 1234 | 0.0 |
| Gene3D | G3DSA:1.10.288.10 | - | - | - | 940 | 1097 | 0.0 |
| Pfam | PF02965 | Vitamin B12 dependent methionine synthase, activation domain | IPR004223 | Vitamin B12-dependent methionine synthase, activation domain | 941 | 1218 | 1.3E-119 |
Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.