Pseudomonas aeruginosa PAO1, PA4356 (xenB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4356
Name
xenB
Replicon chromosome
Genomic location 4883607 - 4884659 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_253046.1
GI 15599552
Affymetrix PA4356_xenB_at
Entrez 881382
GenBank AAG07744.1
INSDC AAG07744.1
NCBI Locus Tag PA4356
protein_id(GenBank) gb|AAG07744.1|AE004851_12|gnl|PseudoCAP|PA4356
TIGR NTL03PA04357
UniParc UPI00000C5CDB
UniProtKB Acc Q9HW45
UniProtKB ID Q9HW45_PSEAE
UniRef100 UniRef100_W0YYL6
UniRef50 UniRef50_Q5NLA1
UniRef90 UniRef90_A6VB28

Product

Feature Type CDS
Coding Frame 1
Product Name
xenobiotic reductase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
Charge (pH 7) -10.37
Kyte-Doolittle Hydrophobicity Value -0.179
Molecular Weight (kDa) 37.8
Isoelectric Point (pI) 4.90

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 506 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003949 (532 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4356
Search term: xenB

Human Homologs

References

Cloning and sequence analysis of two Pseudomonas flavoprotein xenobiotic reductases.
Blehert DS, Fox BG, Chambliss GH
J Bacteriol 1999 Oct;181(20):6254-63
PubMed ID: 10515912
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994