Pseudomonas aeruginosa PAO1, PA3724 (lasB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Ontology

Ontology Accession Term GO Evidence Evidence Ontology (ECO) Code Reference Comments
Biological Process GO:0044267 cellular protein metabolic process
IDA
Inferred from Direct Assay 		ECO:0000002
direct assay evidence
Biological Process GO:0043952 protein transport by the Sec complex
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 9642203 Reviewed by curator
Biological Process GO:0044010 single-species biofilm formation
IMP
Inferred from Mutant Phenotype 		ECO:0000016
loss-of-function mutant phenotype evidence		 18245294 Reviewed by curator
Biological Process GO:0015628 protein secretion by the type II secretion system
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 9642203 Reviewed by curator
Biological Process GO:0006508 proteolysis
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 1597429 Reviewed by curator
Biological Process GO:0060309 elastin catabolic process
ISS
Inferred from Sequence or Structural Similarity 		ECO:0000250
sequence similarity evidence used in manual assertion		 2842313 Reviewed by curator
Biological Process GO:0051542 elastin biosynthetic process
IGI
Inferred from Genetic Interaction 		ECO:0000316
genetic interaction evidence used in manual assertion		 1902216 Reviewed by curator
Biological Process GO:0071978 bacterial-type flagellum-dependent swarming motility
IMP
Inferred from Mutant Phenotype 		ECO:0000315
mutant phenotype evidence used in manual assertion		 18245294 Reviewed by curator
Biological Process GO:0060309 elastin catabolic process
IGI
Inferred from Genetic Interaction 		ECO:0000316
genetic interaction evidence used in manual assertion		 1902216 Reviewed by curator
Biological Process GO:0052051 obsolete interaction with host via protein secreted by type II secretion system
IDA
Inferred from Direct Assay 		ECO:0000314
direct assay evidence used in manual assertion		 15123664 Reviewed by curator
Biological Process GO:0071978 bacterial-type flagellum-dependent swarming motility
IMP
Inferred from Mutant Phenotype 		ECO:0000016
loss-of-function mutant phenotype evidence		 18245294 Reviewed by curator
Biological Process GO:0044010 single-species biofilm formation
IMP
Inferred from Mutant Phenotype 		ECO:0000315
mutant phenotype evidence used in manual assertion		 18245294 Reviewed by curator
Biological Process GO:0006508 proteolysis
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00730
 ECO:0000259
match to InterPro signature evidence used in automatic assertion
Molecular Function GO:0004222 metalloendopeptidase activity
ISM
Inferred from Sequence Model
Term mapped from: InterPro:PR00730
 ECO:0000259
match to InterPro signature evidence used in automatic assertion

Functional Classifications Manually Assigned by PseudoCAP

Secreted Factors (toxins, enzymes, alginate) Other PAO1 genes in this class
Translation, post-translational modification, degradation Other PAO1 genes in this class

Pathways

Database Xref Pathway Version Evidence PMID
PseudoCAP Xcp type II secretion system ECO:0000037
not_recorded
KEGG pae02024 Quorum sensing 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion
KEGG pae01503 Cationic antimicrobial peptide (CAMP) resistance 81.0+/01-23, Jan 17 ECO:0000249
sequence similarity evidence used in automatic assertion

Functional Predictions from Interpro

Analysis Accession Description Interpro Accession Interpro Description Amino Acid Start Amino Acid Stop E-value
Gene3D G3DSA:3.10.450.490 - - - 30 115 1.1E-11
PANTHER PTHR33794 BACILLOLYSIN - - 34 492 7.3E-104
Pfam PF07504 Fungalysin/Thermolysin Propeptide Motif IPR011096 FTP domain 56 90 3.0E-6
Gene3D G3DSA:3.10.450.40 - - - 118 197 4.2E-22
Pfam PF03413 Peptidase propeptide and YPEB domain IPR025711 PepSY domain 123 192 8.8E-9
Gene3D G3DSA:3.10.170.10 - - - 198 349 1.8E-56
FunFam G3DSA:3.10.170.10:FF:000002 Elastase - - 198 349 9.9E-98
SUPERFAMILY SSF55486 Metalloproteases ("zincins"), catalytic domain - - 199 494 1.41E-88
Pfam PF01447 Thermolysin metallopeptidase, catalytic domain IPR013856 Peptidase M4 domain 208 345 3.4E-33
CDD cd09597 M4_TLP - - 234 492 8.53745E-101
PRINTS PR00730 Thermolysin metalloprotease (M4) family signature IPR023612 Peptidase M4 302 322 5.8E-26
PRINTS PR00730 Thermolysin metalloprotease (M4) family signature IPR023612 Peptidase M4 336 352 5.8E-26
Pfam PF02868 Thermolysin metallopeptidase, alpha-helical domain IPR001570 Peptidase M4, C-terminal 348 492 1.0E-36
Gene3D G3DSA:1.10.390.10 Neutral Protease Domain 2 IPR027268 Peptidase M4/M1, CTD superfamily 350 497 3.5E-49
PRINTS PR00730 Thermolysin metalloprotease (M4) family signature IPR023612 Peptidase M4 357 368 5.8E-26
PRINTS PR00730 Thermolysin metalloprotease (M4) family signature IPR023612 Peptidase M4 419 435 5.8E-26

Search for additional functional domains at the NCBI CDD database website. Go to this protein's amino acid sequence and follow the link.