Pseudomonas aeruginosa PAO1, PA2863 (lipH)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA2863
Name
lipH
Synonym: lif
Replicon chromosome
Genomic location 3215423 - 3216289 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_251553.1
GI 15598059
Affymetrix PA2863_lipH_at
DNASU PaCD00007249
Entrez 882663
GenBank AAG06251.1
INSDC AAG06251.1
NCBI Locus Tag PA2863
protein_id(GenBank) gb|AAG06251.1|AE004712_11|gnl|PseudoCAP|PA2863
TIGR NTL03PA02863
UniParc UPI000012E696
UniProtKB Acc Q01725
UniProtKB ID LIFO_PSEAE
UniRef100 UniRef100_Q01725
UniRef50 UniRef50_Q01725
UniRef90 UniRef90_Q01725

Product

Feature Type CDS
Coding Frame 1
Product Name
lipase modulator protein
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -6.74
Kyte-Doolittle Hydrophobicity Value -0.538
Molecular Weight (kDa) 32.4
Isoelectric Point (pI) 4.86

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 1
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6GSF CHAPERONE 06/14/18 Solution structure of lipase binding domain LID1 of foldase from Pseudomonas aeruginosa Pseudomonas aeruginosa PAO1 NOT SOLUTION NMR 98.8
5OVM CHAPERONE 08/29/17 Solution structure of lipase binding domain LID1 of foldase from Pseudomonas aeruginosa Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) NOT SOLUTION NMR 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 27 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002706 (326 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA2863
Search term: lipH

Human Homologs

References

Bacterial lipases.
Jaeger KE, Ransac S, Dijkstra BW, Colson C, van Heuvel M, Misset O
FEMS Microbiol Rev 1994 Sep;15(1):29-63
PubMed ID: 7946464
Purification, molecular cloning, and expression of lipase from Pseudomonas aeruginosa.
Chihara-Siomi M, Yoshikawa K, Oshima-Hirayama N, Yamamoto K, Sogabe Y, Nakatani T, Nishioka T, Oda J
Arch Biochem Biophys 1992 Aug 1;296(2):505-13
PubMed ID: 1632642