Pseudomonas aeruginosa PAO1, PA0678 (hxcU)

Annotation Updates

Date	Description	Acknowledgements
May 12, 2006	New structure feature: Manually-identified prepilin peptidase substrate (type IV) export signal (MRRPRQSGFTLIE)	Lewenza S, Gardy JL, Brinkman FS, Hancock RE
May 8, 2015	New gene name: hxcU. New product name: HxcU. New product name confidence: Class 1.	Rome Voulhoux, CNRS, Marseille, France
Jun 10, 2004	Annotation of gene previously described as probable type II secretion system protein (Class 3). New protein name: HxcU putative pseudopilin. New evidence reference (PubMed ID): 11985723. Hew homology added: 54% identical and 78% similar to XcpT[Pseudomonas aeruginosa]. New genomic context added: 54% identical and 78% similar to XcpT[Pseudomonas aeruginosa]. New structure features: The leader peptide extends between residues 1 to 8, and includes the invariant glycine after which cleavage by the prepilin peptidase takes place. The new N-terminal residue is phenylalanine, and precedes 24 highly hydrophobic residues. New comments: The fifth residue of the mature sequence is a glutamate, which seems important in the methylation of this class of proteins. Hxc proteins are involved in alkaline phosphatase secretion. hxc gene cluster is under phosphate regulation. Belongs to general secretory pathway protein H family.	Raymond C. Lo and Fiona S.L. Brinkman, Simon Fraser University, Canada (based on literature review);